Digestive Diseases and Sciences

, Volume 25, Issue 1, pp 53–58

Comparison of the one-gramd-[14C]xylose breath test to the [14C]bile acid breath test in patients with small-intestine bacterial overgrowth

  • Charles E. King
  • Phillip P. Toskes
  • Tomas R. Guilarte
  • Erhard Lorenz
  • Susan L. Welkos
Original Articles
  • 29 Downloads

Abstract

In twelve patients with culture-proven bacterial overgrowth of the small intestine, the ability of a newly-developed one-gramd-[14C]xylose breath test to detect bacterial overgrowth was compared to that of the [14C]bile acid breath test. All patients manifested excessive production of breath14CO2 after the administration of one gram [14C]xylose, with 83% of the patients being abnormal within the first hour of testing. In contrast, during the [14C]bile acid breath test, four of the twelve patients had no period of excessive14CO2 production (above the 95% confidence range of controls). Nutrient malabsorption (fat, cobalamin, xylose) was seen with both true-positive and false-negative bile acid breath tests. The one gram [14C]xylose breath test, utilizing a substrate with more predominant absorption in the proximal small intestine and which can be catabolized by Gram-negative aerobic bacteria, appears to have a greater degree of sensitivity and specificity than the bile acid breath test in detecting the presence of small-intestine bacterial overgrowth.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Digestive Disease Systems, Inc. 1980

Authors and Affiliations

  • Charles E. King
    • 1
    • 2
  • Phillip P. Toskes
    • 1
    • 2
  • Tomas R. Guilarte
    • 1
    • 2
  • Erhard Lorenz
    • 1
    • 2
  • Susan L. Welkos
    • 1
    • 2
  1. 1.Gastroenterology sectionVeterans Administration Medical CenterGainesville
  2. 2.the Departments of Medicine, Radiology, and Medical MicrobiologyUniversity of Florida College of MedicineGainesville

Personalised recommendations