Digestive Diseases and Sciences

, Volume 32, Supplement 12, pp S71–S75 | Cite as

Double-blind, placebo-controlled evaluation of 5-ASA suppositories in active distal proctitis and measurement of extent of spread using99mTc-labeled 5-ASA suppositories

  • C. N. William
  • G. Haber
  • J. A. Aquino
Article

Abstract

Patients with active distal proctitis received either 5-aminosalicylic (5-ASA) acid or identical placebo suppositories, 500mg t.i.d. for 6 weeks. Activity at 3 and 6 wks was assessed using a Disease Activity Index (DAI), derived from four categories: number of daily evacuations more than usual, evacuations containing blood, sigmoidoscopy appearance, and physician's overall assessment. Each category was graded 0–3. There was thus 0–12 points scored ranging from complete remission to severe disease. A minimum score of 3 from two categories was necessary for study entry. Of 27 patients randomized, 14 received active medication and 13 placebo. Of the 14 patients, with initial mean DAI 7.1 ±1.8, 11 were in complete remission at 6 wks (78.6%). Whereas, there was no significant change in the placebo group, with initial mean DAI 7.1±1.8. An additional 6 patients with inflammatory bowel disease and 6 healthy volunteers were given99mTc-labelled 5-aminosalicylic acid suppositories. The extent of spread was limited to the rectum, and the suppositories were retained for 3 hours. There was no absorbed radioactivity. 5-ASA suppositories are safe, well-tolerated, and effective treatment for active distal proctitis.

Key Words

5-aminosalicylic acid distal proctitis 99mTc-labelled 5-ASA disease activity index 

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Copyright information

© Plenum Publishing Corporation 1987

Authors and Affiliations

  • C. N. William
    • 1
    • 2
  • G. Haber
    • 1
    • 2
  • J. A. Aquino
    • 1
    • 2
  1. 1.Department of Medicine and Nuclear MedicineDalhousie UniversityHalifaxCanada
  2. 2.University of TorontoTorontoCanada

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