Archives of Virology

, Volume 111, Issue 3–4, pp 275–280 | Cite as

In vitro isolation of a neutralization escape mutant of equine infectious anemia virus (EIAV)

  • P. M. Rwambo
  • C. J. Issel
  • K. A. Hussain
  • R. C. Montelaro
Brief Report


A neutralization escape mutant (A/1 E) of equine infectious anemia virus was isolated after 13 passages in cell culture in the presence of serum containing antibodies to type- and group-specific determinants of EIAV envelope glycoproteins. Loss of neutralization by the selecting serum correlated with loss of two epitopes in the major envelope glycoprotein gp90 of A/1 E which were present in a parallel variant isolated from a persistently infected pony.


Cell Culture Infectious Disease Anemia Envelope Glycoprotein Escape Mutant 
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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • P. M. Rwambo
    • 1
  • C. J. Issel
    • 1
    • 2
  • K. A. Hussain
    • 1
  • R. C. Montelaro
    • 3
  1. 1.Department of Veterinary Microbiology and ParasitologyLouisiana State University School of Veterinary MedicineBaton RougeU.S.A
  2. 2.Department of Veterinary ScienceLouisiana State University Agricultural CenterBaton RougeU.S.A.
  3. 3.Department of Biochemistry, Louisiana Agricultural Experiment StationLouisiana State University Agricultural CenterBaton RougeU.S.A.

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