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Archives of Virology

, Volume 99, Issue 1–2, pp 89–100 | Cite as

Antiviral activity of a synthetic analog of prostaglandin A in mice infected with influenza A virus

  • M. G. Santoro
  • C. Favalli
  • A. Mastino
  • B. M. Jaffe
  • M. Esteban
  • E. Garaci
Original Papers

Summary

We have previously shown that prostaglandins of the A series potently inhibit virus replication in several virus-host systems in vitro. In the present report we have studied the effect of a long-acting synthetic analog of PGA, 16,16-dimethyl-PGA2 (Di-M-PGA2), on virus infection in vivo, using as a model Balb/c mice infected with influenza A (PR8) virus. Depending upon the dose of viral inoculum, PR8 virus caused the death of 50 to 100% of the animals in a period of 8–20 days. Di-M-PGA2-treatment significantly increased mouse survival by an average of 40%, independently of the dose of inoculum and the age of the animals. The fact that Di-M-PGA2-treatment decreased virus titers in the lungs and did not alter the host immune response, suggested that PGA's therapeutic action was due to suppression of virus replication. Finally, two anti-inflammatory compounds, which inhibit prostaglandin synthesis, aspirin and indomethacin, were shown not to significantly alter mouse survival in this system.

Keywords

Influenza Aspirin Prostaglandin Indomethacin Virus Replication 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • M. G. Santoro
    • 1
  • C. Favalli
    • 2
  • A. Mastino
    • 2
  • B. M. Jaffe
    • 3
  • M. Esteban
    • 4
  • E. Garaci
    • 2
  1. 1.Institute of Experimental Medicine, C.N.R.II University of RomeRomeItaly
  2. 2.Department of Experimental MedicineII University of RomeRomeItaly
  3. 3.Department of SurgeryS.U.N.Y., Downstate Medical CenterBrooklyn, New YorkU.S.A.
  4. 4.Department of BiochemistryS.U.N.Y., Downstate Medical CenterBrooklyn, New YorkU.S.A.

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