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Archives of Virology

, Volume 93, Issue 3–4, pp 247–260 | Cite as

Replication of human adenoviruses in guinea pig embryo cells: an ultrastructural study

  • Caroline K. Y. Fong
  • Marie L. Landry
  • G. D. Hsiung
Original Papers

Summary

Guinea pig embryo (GPE) cells showed different degrees of susceptibility to human adenovirus types as determined by virus infectivity assay and electron microscopic examination. Adenovirus 2 and 5 induced extensive cellular changes and produced high titers of infectious virus in GPE cells as in human cells. Mature progeny virus and protein crystals were observed in both cell types. Adenovirus 7 induced some cellular changes in GPE cells but only a small number of cells yielded progeny virus as determined by electron microscopy. Adenovirus 3, 8 and 31 induced some cellular changes but no progeny virus was found under electron microscopic examination. Characteristic fibers were observed in nuclei of adenovirus 31 infected cells. The ability of human adenovirus 2 and 5 to replicate in GPE cells is an example of an unusual cross-species biological property of certain adenovirus types. This property may be useful as a biological marker for these virus types.

Keywords

Infected Cell Biological Property Virus Type High Titer Biological Marker 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • Caroline K. Y. Fong
    • 1
    • 2
  • Marie L. Landry
    • 1
    • 2
  • G. D. Hsiung
    • 1
    • 2
  1. 1.Virology LaboratoryVeterans Administration Medical CenterWest HavenU.S.A.
  2. 2.Department of Laboratory MedicineYale University School of MedicineNew HavenU.S.A.

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