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Archives of Virology

, Volume 93, Issue 3–4, pp 213–222 | Cite as

AEV-transformed erythroleukemia cell induced differentiation: Expression of specific cell membrane antigenic molecules

  • I. Raynaud
  • J. M. Biquard
  • P. Chambard
  • B. Fasciotto
  • J. Samarut
  • J. P. Blanchet
  • V. Krsmanovic
Original Papers

Summary

A simultaneous decay of the expression of Im 140 kDa, Im 150 kDa and Im 160 kDa high MW membrane antigens, concomitant with the cell proliferation arrest, was observed during erythropoietin induced differentiation ofts 34 AEV-transformed erythroid cells cultivated at the restrictive temperature. Expression of embryo-immature antigens was maintained during induced differentiation of erythroleukemia cells, but their MW shifted from 50 to 48 kDa, which corresponds to the MW of embryo-immature antigens detected on normal erythroid cells. In the absence of erythropoietin at the restrictive temperature, conditions under which thets 34 AEV-transformed erythroid cells fail to differentiate and maintain their capacity to proliferate, the expression of high MW antigens as well as the expression of embryoimmature antigens remained unaffected. Therefore, it is shown that the expression of specific membrane antigens is modulated under conditions rendering the erythroleukemia cell differentiation process possible.

Keywords

Cell Proliferation Infectious Disease Cell Differentiation Erythropoietin Differentiation Process 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • I. Raynaud
    • 1
  • J. M. Biquard
    • 2
  • P. Chambard
    • 1
  • B. Fasciotto
    • 1
  • J. Samarut
    • 3
  • J. P. Blanchet
    • 3
  • V. Krsmanovic
    • 1
  1. 1.Unité de Virologie INSERM U 51LyonFrance
  2. 2.Institut du RadiumOrsayFrance
  3. 3.Département de Biologie Générale et AppliquéeUniversité Claude BernardVilleurbanneFrance

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