Archives of Virology

, Volume 120, Issue 1–2, pp 135–143 | Cite as

The capsid protein-encoding sequence of foot-and-mouth disease virus O2Brescia

  • O. Krebs
  • H. G. Berger
  • O. Marquardt
Brief Report


Nucleotide sequences encoding the four capsid proteins of foot-and-mouth disease virus subtype O2Brescia/1947 have been determined. These and the deduced amino acid sequences were compared with those of a subtype O1 virus strain. The nucleotide sequences differed at 259 positions, causing only 35 amino acid changes. VP 4 and VP 2 differed by 2.4 and 1.8%, whereas VP 1, known as major viral antigen, and VP 3 differed by 8% and 5.5%, respectively. The differences occur mainly in protein domains not involved in the formation of α-helices and β-sheets, suggesting that the surfaces of both viruses are more variable than their scaffolds. The O2Brescia sequence has been submitted to the GenBank data base and has the accession number M 55287.


Nucleotide Infectious Disease Amino Acid Sequence Nucleotide Sequence Accession Number 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • O. Krebs
    • 1
  • H. G. Berger
    • 2
  • O. Marquardt
    • 1
  1. 1.Federal Research Centre for Virus Diseases of AnimalsTübingenGermany
  2. 2.Friedrich Miescher Laboratory of the Max-Planck-SocietyTübingenGermany

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