Archives of Virology

, Volume 80, Issue 2–3, pp 119–130 | Cite as

Differing cardiotropic and myocarditic properties of group B type 4 coxsackievirus strains

  • Yiyun Cao
  • D. P. Schnurr
  • Nathalie J. Schmidt
Article

Summary

A murine model system for evaluation of myocarditic and cardiotropic properties of strains of group B, type 4 coxsackievirus (CBV-4) was developed in male BALB/c mice 4 weeks of age. Differing cardiotropic and myocarditic properties could be identified among field strains within the CBV-4 serotype. These properties were consistent for the virus strains, and were independent of the infecting virus dose. Virus replication in the heart appeared to be essential for development of myocarditis, but some infected hearts with high levels of infectious virus did not show myocarditis. Two of the myocarditic strains showed different histopathology in infected hearts; with one strain (Mil) the myocarditis was characterized by a marked inflammatory reaction with occasional accompanying myofiber necrosis. With the other strain (Bol), necrosis was the predominant finding, with a much lesser degree of inflammation. These findings suggest that there may be various pathogenic or immunopathogenic mechanisms by which CBV-4 can produce myocarditis.

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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • Yiyun Cao
    • 1
  • D. P. Schnurr
    • 2
  • Nathalie J. Schmidt
    • 3
  1. 1.Institute of Medical BiologyChinese Academy of Medical SciencesKunmingPeople's Republic of China
  2. 2.Center for Advanced Medical TechnologySan Francisco State UniversitySan Francisco
  3. 3.Viral and Rickettsial Disease LaboratoryCalifornia Department of Health ServicesBerkeleyU.S.A.

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