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Archives of Virology

, Volume 135, Issue 1–2, pp 159–164 | Cite as

A field isolate of Sendai virus: its high virulence to mice and genetic divergence from prototype strains

  • T. Sakaguchi
  • K. Kiyotani
  • M. Sakaki
  • Y. Fujii
  • T. Yoshida
Brief Report

Summary

A field isolate of Sendai virus, the Hamamatsu strain, was far more virulent in mice than the prototype Z strain. The Hamamatsu strain replicated more efficiently in the mouse lung than the Z strain, causing deteriorating lung lesions. Nucleotide sequence analysis of the HN, F and M genes revealed that the Hamamatsu strain was divergent from the prototype Z, Harris and Fushimi strains.

Keywords

Nucleotide Genetic Divergence Infectious Disease Sequence Analysis Nucleotide Sequence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • T. Sakaguchi
    • 1
  • K. Kiyotani
    • 1
  • M. Sakaki
    • 1
  • Y. Fujii
    • 1
  • T. Yoshida
    • 1
  1. 1.Department of BacteriologyHiroshima University School of MedicineHiroshimaJapan

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