Digestive Diseases and Sciences

, Volume 26, Issue 9, pp 807–816 | Cite as

Granular cell tumors of the gastrointestinal tract and perianal region A study of 74 cases

  • Major James Johnston
  • Elson B. Helwig
Original Articles

Abstract

Seventy-four patients with 75 examples of granular cell tumors occurring in the gastrointestinal tract and perianal region were studied. Twenty-four were located in the esophagus, eight in the stomach, three in the small bowel, four in the appendix, twenty in the large bowel, and sixteen in the perianal region. Nine cases had multiple tumors either occurring in the same area of the bowel or in other organs, mostly the skin. Approximately 50% of the tumors occurring in the esophagus and perianal region showed varying degrees of acanthosis or pseudoepitheliomatous hyperplasia. In the perianal tumors the pseudoepitheliomatous hyperplasia was much more extensive and could be mistaken for squamous cell carcinoma. The world literature was reviewed and a total of 66 cases of granular cell tumors were reported in the area of study. In neither our 74 nor the other reported cases was there evidence of recurrence or malignant behavior of the tumors, thus confirming their benign biologic behavior.

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References

  1. 1.
    Abrikossoff AI: Uber Myome, ausgehend von der quergestneiften willkurlichen Muskulatur. Virchows Arch Pathol Anat 260:214–233, 1926Google Scholar
  2. 2.
    Moscovic EA, Azar HA: Multiple granular cell tumor (“myoblastoma”). Case report with electron microscope observations and review of the literature. Cancer 20:2032–2037, 1967Google Scholar
  3. 3.
    Azzopardi JC: Histogenesis of the granular cell “myoblastoma.” J Pathol Bacteriol 71:85–94, 1956Google Scholar
  4. 4.
    Gray SH, Gruenfeld GE: Myoblastoma. Am J Cancer 30:699–708, 1937Google Scholar
  5. 5.
    Sobel HJ, Churg J: Granular cells and granular cell lesions. Arch Pathol 77:132–141, 1964Google Scholar
  6. 6.
    Sobel HJ, Marquet E, Avrin E, Schwarz R: Granular cell myoblastoma. An electron microscopic and cytochemical study illustrating the genesis of granules and aging of myoblastoma cells. Am J Pathol 65:59–71, 1971Google Scholar
  7. 7.
    Ackerman LV, Rosai J: Surgical Pathology, 5th ed. St. Louis, CV Mosby, 1974, p 1156Google Scholar
  8. 8.
    Christ ML, Ozzello L: Myogenous origin of a granular cell tumor of the urinary bladder. Am J Clin Pathol 56:736–749, 1971Google Scholar
  9. 9.
    Murray MR: Cultural characteristics of three granular cell myoblastomas. Cancer 4:857–865, 1951Google Scholar
  10. 10.
    Fust JA, Custer RP: On the neurogenesis of so-called granular cell myoblastoma. Am J Clin Pathol 19:522–535, 1949Google Scholar
  11. 11.
    Pearce AG: The histogenesis of granular cell myoblastoma (granular cell perineural fibroblastoma). J Pathol 62:351–362, 1950Google Scholar
  12. 12.
    Budzilovich GN: Granular cell “myoblastoma” of vagus nerve. Acta Neuropathol (Berlin) 10:162–165, 1968Google Scholar
  13. 13.
    Feyrter F: Uber eine eigenartige Geschwulstform des Nervengewekes in menschlichen Verdaungschlauch. Virchows Arch Pathol Anat 295:480–501, 1935Google Scholar
  14. 14.
    Fisher ER, Wechsler H: Granular cell myoblastoma—a misnomer. Electron microscopic and histochemical evidence concerning its Schwann cell derivation and nature (granular cell schwannoma). Cancer 15:396–454, 1962Google Scholar
  15. 15.
    Garancis JC, Komorowski RA, Kurzma JF: Granular cell myoblastoma. Cancer 25:542–550, 1970Google Scholar
  16. 16.
    Navarette AR, Smith M: Ultrastructure of granular cell ameloblastoma. Cancer 27:948–955, 1971Google Scholar
  17. 17.
    Alkek DS, Johnson WC, Graham JH: Granular cell myoblastoma: A histological and enzymatic study. Arch Dermatol 98:543–547, 1968Google Scholar
  18. 18.
    Krieg AF: Malignant granular cell myoblastoma: Report of a case. Arch Pathol 74:251–256, 1962Google Scholar
  19. 19.
    Al-Sarraf M, Loud AV, Vaitkevicius VK: Matlignant granular cell tumor. Histochemical and electron microscopic study. Arch Pathol 91:550–588, 1971Google Scholar
  20. 20.
    Usui M, Ishii S, Yamawaki S: Malignant granular cell tumor of the radial nerve. An autopsy observation with electron microscopic and tissue culture studies. Cancer 39:1547–1555, 1977Google Scholar
  21. 21.
    Bloustein PA: The nature of the granules in the granular cell tumor. An ultrastructural study. Lab Invest 34:309, 1976 (abstract)Google Scholar
  22. 22.
    Carstens PHB: Ultrastructure of granular cell myoblastoma. Acta Pathol Microbiol Scand 78:685–694, 1970Google Scholar
  23. 23.
    Kanabe S, Watanabe I, Lotuaco L: Multiple granular cell tumors of the ascending colon. Dis Colon Rectum 21:322–328, 1978Google Scholar
  24. 24.
    Abrikossoff AI: Weitere Untersuchungen uber Myoblastenmyome. Virchows Arch Pathol Anat 280:723–740, 1931Google Scholar
  25. 25.
    Naidech HJ, Axelrod RS, Selinger G: Granular cell tumor (myoblastoma) of the stomach. Am J Roentgenol 113:245–247, 1971Google Scholar
  26. 26.
    Sobel HJ, Marquet E, Schwarz R: Granular degeneration of appendiceal smooth muscle. Arch Pathol 92:427–432, 1971Google Scholar
  27. 27.
    Crane AR, Tremblay RG: Myoblastoma (granular cell myoblastoma or myoblastic myoma). Am J Pathol 21:357–375, 1945Google Scholar
  28. 28.
    Rickert RR, Harkey IG, Bocar Kantor E: Granular cell tumors (myoblastomas) of the anal region. Dis Colon Rectum 21:413–417, 1978Google Scholar
  29. 29.
    Rosenberg I: Perianal granular cell myoblastoma: Report of a case. J Int Coll Surg 33:346–351, 1960Google Scholar
  30. 30.
    Crawford ES, Debakey ME: Granular cell myoblastoma in two unusual cases. Cancer 6:786–789, 1953Google Scholar
  31. 31.
    Degouveia OF, Pereira AA, Netto MB, Vilhena AM, Dutra G, Bryk D: Granular cell myoblastoma of the esophagus (Abrikossoff's tumor). Gastroenterol 38:805–809, 1960Google Scholar
  32. 32.
    Obiditsch-Mayer I, Saler-Kunt-Schik M: Malignes (gekorntzelliges Neurom) Sogenn antes (Myoblastenmyom) des esophagus. Beitr Pathol Anat 125:357–373, 1961Google Scholar
  33. 33.
    Keshishian JH, Alford TC: Granular cell myoblastoma of the esophagus. Report of a case. Am Surg 30:263–266, 1964Google Scholar
  34. 34.
    Stout AP, Lattes R: Atlas of Tumor Pathology, 2ed, Vol 1, Tumors of the Soft Tissues. Washington DC, Armed Forces Institute of Pathology, 1967, p 92Google Scholar
  35. 35.
    Wypkema W, Schmaman A, Benson D: Granular cell myoblastoma of the esophagus. A report of two cases. S Afr Med J 41:911–914, 1967Google Scholar
  36. 36.
    Flege JB, Edmonds TT: Granular cell myoblastoma of the esophagus. A case report. J Thorac Cardiovasc Surg 58:217–220, 1969Google Scholar
  37. 37.
    Paskin DL, Hull JD, Cookson PJ: Granular cell myoblastoma: A comprehensive review of 15 years experience. Ann Surg 175:501–503, 1972Google Scholar
  38. 38.
    Rella AJ, Conte AJ, Farrell JT: Granular cell myoblastoma of the esophagus. A case report. Arch Otol (St. Louis) 78:715–718, 1963Google Scholar
  39. 39.
    Farrell KH, Devine K, Harrison EG, Olsen AM: Granular cell myoblastoma of the esophagus. Incidence and surgical treatment. Ann Otol (St. Louis) 82:784–789, 1973Google Scholar
  40. 40.
    Larsen GL, Armstrong RG, Stanford DW, Cline R: Granular cell myoblastoma of the esophagus. Thorax 28:641–643, 1973Google Scholar
  41. 41.
    Hugh S, Collett MD: Granular cell myoblastoma of the esophagus. Rocky Mt Med J 71:145–147, 1974Google Scholar
  42. 42.
    Saurel J, Doutre LP, Crosson F, Richir A, Delorme G: Tumeur d'Abrikossoff a locatisation esophagienne. Sem Hop Paris 54:1073–1079, 1978Google Scholar
  43. 43.
    Benjenou A, Germain M, Gremillet C, Lesec G, Delaviere PH: Tumeur a cellules granuleuses, dite tumeur d'Abrikossoff de l'oesophage. Sem Hop Paris 55:1177–1179, 1979Google Scholar
  44. 44.
    Domen RE, Tang P, Harshman KV: Granular cell myoblastoma of the esophagus after irradiation for carcinoma. South Med J 72:1207–1209, 1979Google Scholar
  45. 45.
    Stout AP: Atlas of Tumor Pathology, 1 ed, Vol 5, Tumors of the Soft Tissue. Washington DC, Armed Forces Institute of Pathology, 1953Google Scholar
  46. 46.
    Goodman ML, Gottlieb L, Zamcheck N: Granular cell myoblastoma of the stomach and colon. Am J Dig Dis 7:432–441, 1962Google Scholar
  47. 47.
    Schwarz DT, Gaetz HP: Multiple granular cell myoblastoma of the stomach. Am J Clin Pathol 44:453–457, 1965Google Scholar
  48. 48.
    Liubushing AA: Abrikossoff's tumor in the stomach. Arkh Pat (Russian) 30:88–90, 1968Google Scholar
  49. 49.
    Murray DE, Seaman E, Utzinger W: Granular cell myoblastoma in successive generations. J Surg Oncol 1:193–197, 1969Google Scholar
  50. 50.
    Strong EW, McDivitt RW, Brashfield RD: Granular cell myoblastoma. Cancer 25:415–522, 1970Google Scholar
  51. 51.
    Goodman MD, Cooper PH: Granular cell tumor of the stomach. A case report with ultrastructural findings and review of the literature. Am J Dig Dis 17:1117–1125, 1972Google Scholar
  52. 52.
    Aston SJ, Tompkins RK: Granular cell myoblastoma of the stomach. Ann Surg 177:215–231, 1973Google Scholar
  53. 53.
    Krouse TB, Mobini J: Multifocal myoblastoma. Report of a case involving trachea, stomach and anterior abdominal wall. Arch Pathol 96:95–99, 1973Google Scholar
  54. 54.
    Ming SC: Atlas of Tumor Pathology, 2 ed Vol 7, Tumors of the Esophagus and Stomach. Washington DC, Armed Forces Institute of Pathology, 1973Google Scholar
  55. 55.
    Miranda D: Benign granular cell tumor (“myoblastoma”) of the stomach. Am J Gastroenterol 65:344–348, 1976Google Scholar
  56. 56.
    Abouchedid C, Philo SS, Shetty SH: Granular cell myoblastoma of the stomach. J Med Soc NJ 74:972–975, 1977Google Scholar
  57. 57.
    Ghazi A: Combined granular cell tumor of stomach and cecum. Mt Sinai J Med 146:195–198, 1979Google Scholar
  58. 58.
    Churg J, Work J: Granular cell nodules of the gastrointestinal tract. Am J Pathol 35:692–693, 1959 (abstract)Google Scholar
  59. 59.
    Hunter DT Jr, Dewar JP: Malignant granular cell myoblastoma. Report of a case and review of the literature. Am Surg 26:554–559, 1960Google Scholar
  60. 60.
    Cohen RS, Cramm RE: Granular cell myoblastoma—an unusual rectal neoplasm: Report of a case. Dis Colon Rectum 12:120–124, 1969Google Scholar
  61. 61.
    Harkin JC, Reed RJ: Atlas of Tumor Pathology, 2 ed, Vol 3, Tumors of the Peripheral Nervous System. Washington DC, Armed Forces Institute of Pathology, 1969Google Scholar
  62. 62.
    Donahoo JS, McSwain B: Granular cell myoblastoma of the cecum; a case report. Am Surg 36:565–568, 1970Google Scholar
  63. 63.
    Paris J, Ribet M, Dupont A, Paris JC, Houcke Bray G: Localisations rectales et cutanees des lumens acellules granuleuses d'Abrikossoff. Sem Hop Paris 50:1219–1221, 1974Google Scholar
  64. 64.
    Weitzner S, Lockard VG, Nascimento AG: Granular cell myoblastoma of the cecum. Report of a case. Dis Colon Rectum 19:675–679, 1976Google Scholar
  65. 65.
    Simon MA: Granular cell myoblastoma (myoblastic myoma, rhabdomyome granulo-cellulaire). Am J Clin Pathol 17:302–313, 1947Google Scholar
  66. 66.
    Rothchild TP, Crary RH: Granular cell myoblastoma: A report of five cases. Ann Surg 137:530–538, 1953Google Scholar
  67. 67.
    Winne BE, Bacon HE: Myoblastoma of the anal canal. Dis Colon Rectum 4:206–214, 1961Google Scholar
  68. 68.
    Vance SF, Hudson RP: Granular cell myoblastoma: Clinicopathological study of forty-two patients. Am J Pathol 52:208–211, 1969Google Scholar

Copyright information

© Digestive Disease System, Inc 1981

Authors and Affiliations

  • Major James Johnston
    • 1
  • Elson B. Helwig
    • 1
  1. 1.Department of Gastrointestinal PathologyArmed Forces Institute of PathologyWashington, D.C.

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