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Archives of Virology

, Volume 139, Issue 1–2, pp 79–85 | Cite as

Detection of DNA and E7 transcripts of human papillomavirus types 16, 18, 31 and 33, TGFβ and GM-CSF transcripts in cervical cancers and precancers

  • L. Ho
  • G. Terry
  • B. Mansell
  • B. Butler
  • A. Singer
Original Papers

Summary

The association of human papillomavirus (HPV) with a high proportion of cervical cancers should allow the efficiency of cytological screening methods to be improved. We report here that quantitative detection of HPV types 16, 18, 31 and 33 DNA and the corresponding E7 transcripts by polymerase chain reaction (PCR) may be of value in identifying precancers and cancers. In clinical specimens with major cervical lesions, the level of E7 transcription does not appear to be related to concomitant transcription of either transformation growth factor-beta (TGFβ) or granulocyte-macrophage colony stimulating factor (GM-CSF) genes.

Keywords

Cervical Cancer Colony Stimulate Factor Screening Method Stimulate Factor Clinical Specimen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • L. Ho
    • 1
  • G. Terry
    • 2
  • B. Mansell
    • 3
  • B. Butler
    • 3
  • A. Singer
    • 3
  1. 1.Department of Medical MicrobiologyUniversity College LondonLondonUK
  2. 2.Department of Molecular PathologyUniversity College LondonLondonUK
  3. 3.Department of GynaecologyWhittington HospitalLondonUK

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