Advertisement

Digestive Diseases and Sciences

, Volume 26, Issue 6, pp 532–537 | Cite as

Circulating trypsin-like immunoreactivity in chronic pancreatitis

  • A. Andriulli
  • G. Masoero
  • M. Felder
  • I. Vantini
  • M. Petrillo
  • G. Cavallini
  • G. Bianchi Porro
  • G. Dobrilla
  • G. Verme
Original Articles

Abstract

The present study has been designed to work out the factors regulating the fasting serum levels of trypsin-like immunoreactivity in chronic pancreatitis. One hundred patients with chronic pancreatitis have been included and studied during a painless phase of the disease. No relationships have been observed between serum trypsin-like immunoreactivity and the presence of pancreatic calcifications. Serum immunoreactive trypsin levels showed a gradual decline parallel to the progressive impairment of bicarbonate and enzyme (trypsin and chymotrypsin) outputs in duodenal aspirates during pancreatic secretory studies. Therefore, serum trypsin-like immunoreactivity levels are thought to reflect the functional capacity of the exocrine pancreas. Reduced levels of trypsin-like immunoreactivity were detected in almost all patients with diabetes and steatorrhea. However, the finding of low levels also in a minority of chronic pancreatitis patients with normal endoscopic retrograde cholangiopancreatography or pancreatic secretory tests points to other factors which, in addition to the atrophy of the pancreatic parenchyma, may influence the circulating levels of trypsin-like immunoreactivity in chronic pancreatitis.

Keywords

Chronic Pancreatitis Chymotrypsin Endoscopic Retrograde Cholangiopancreatography Fasting Serum Exocrine Pancreas 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Elias E, Redshaw M, Wood T: Diagnostic importance of changes in circulating concentrations of immunoreactive trypsin. Lancet 2:66–68, 1977Google Scholar
  2. 2.
    Gobelet Ch, Bambule J, Felber JP, Magnenat P, Sechaud R: Taux de trypsine radio-immunologique dans la pancreatite chronique. Schwetz Med Wochenschr 108:1902–1904, 1978Google Scholar
  3. 3.
    Adrian TE, Besterman HS, Mallinson CN, Pera A, Redshaw M, Wood TP, Bloom SR: Plasma trypsin in chronic pancreatitis and pancreatic adenocarcinoma. Clin Chim Acta 97:205–212, 1979Google Scholar
  4. 4.
    Koop H, Arnold R, Lankisch PG, Creutzfeldt W: Trypsin radioimmunoassay in the diagnosis of chronic pancreatitis. Proceedings of the XI Symposium of the European Pancreatic Club, Zurich, 1978Google Scholar
  5. 5.
    Lake-Bakaar G, McKavanagh, Redshaw M, Wood T, Summerfield JA, Elias E: Serum immunoreactive trypsin concentration after a Lundh meal. J Clin Pathol 2:1003–1008, 1979Google Scholar
  6. 6.
    Adrian TE, Besterman HS, Mallinson CN, Galarotis C, Bloom SR. Plasma try[sin in the diagnosis of steatorrhea due to chronic pancreatitis. Gut 19:A446, 1978Google Scholar
  7. 7.
    Cavallini G, Mirachian R, Angelini G, Vantini I, Vaona B, Bovo P, Gelpi F, Ederle A, Dobrilla G, Scuro LA: The role of caerulein in tests of exocrine pancreatic function. Scand J Gastroenterol 13:3–15, 1978Google Scholar
  8. 8.
    Figarella C, Taulier J, Sarles H: Dosage de la chymotrypsine et de la trypsine dans le suc duodénal. Bull Soc Chim Biol 47:679–686, 1965Google Scholar
  9. 9.
    Erlanger BF, Kokowsky N, Cohen W: The preparation and properties of two new chromogenic substrate of trypsin. Arch Biochem Biophys 95:271–278, 1961Google Scholar
  10. 10.
    Malvano R, Marchisio M, Massaglia A, Giacosa M, Zannino M, Andriulli A, Burlina A: Radioimmunoassay of trypsin-like substances in human serum, Scand J Gastroenterol 15 (Suppl. 62):3–10, 1980Google Scholar
  11. 11.
    Andriulli A, Recchia S, Masoero G, Pera A, Bonino F, Ponzetto A, Gaia E, Felder M, Verme G, Dobrilla G: Clinical evaluation of serum cationic trypsin-like immunore-activity in patients with different pancreatic diseases. Ital J Gastroenterol 12:260–264, 1980Google Scholar
  12. 12.
    Di Magno EP, Go VLW, Summerskill WHJ: Relations between pancreatic enzyme outputs and malabsorption in severe pancreatic insufficiency. N Engl J Med 288:813–815, 1973Google Scholar
  13. 13.
    Sarles H, Gerolami-Santandrea A: Chronic pancreatitis. Clin Gastroenterol 1:167–193, 1972Google Scholar
  14. 14.
    Di Magno EP, Malagelada SR, Go VLW: Relationship between alcoholism and pancreatic insuffciency. Ann NY Acad Sci 252:200–207, 1975Google Scholar
  15. 15.
    Case RM: Pancreatic secretion: Cellular aspects.In Scientific Basis of Gastroenterology, HL Duthie, KG Wormsley (eds.) London, Churchill Livingstone, 1979 pp 163–198Google Scholar

Copyright information

© Digestive Disease Systems, Inc 1981

Authors and Affiliations

  • A. Andriulli
    • 1
    • 2
    • 3
  • G. Masoero
    • 1
    • 2
    • 3
  • M. Felder
    • 1
    • 2
    • 3
  • I. Vantini
    • 1
    • 2
    • 3
  • M. Petrillo
    • 1
    • 2
    • 3
  • G. Cavallini
    • 1
    • 2
    • 3
  • G. Bianchi Porro
    • 1
    • 2
    • 3
  • G. Dobrilla
    • 1
    • 2
    • 3
  • G. Verme
    • 1
    • 2
    • 3
  1. 1.Gastroenterological Unit of TorinoBolzanoItaly
  2. 2.Gastroenterological Unit of TorinoVeronaItaly
  3. 3.Gastroenterological Unit of TorinoMilanoItaly

Personalised recommendations