Digestive Diseases and Sciences

, Volume 26, Issue 1, pp 33–41 | Cite as

Insulin and myoelectric activity of the small intestine of the pig

  • V. Rayner
  • T. E. C. Weekes
  • J. B. Bruce
Orignal Articles
Received:
Revised:
Accepted:

Abstract

The effect of insulin on the myoelectric activity of the small intestine was determined in conscious pigs. Animals were implanted with electrodes along the small intestine, a strain gage on the stomach and catheters in both saphenous arteries. Feeding modified the migrating myoelectric complex (MMC), a cyclic pattern of action potential activity of the small intestine characteristic of fasting. The first period of regular spiking activity (RSA) on the duodenum after feeding was delayed and was not followed by quiescence. Plasma insulin and glucose concentrations during the first three MMC after feeding were highest just before periods of duodenal RSA. Injection or infusion of insulin into fasted pigs with production of hypoglycemia caused disruption of stomach motility and duodenal electrical activity. The duodenal MMC was not altered when glucose to prevent hypoglycemia was infused together with insulin or when glucose was infused alone. These studies suggest that insulin is not directly responsible for the postprandial modification of MMC activity as insulin infusions only modify the MMC when hypoglycemia occurs.

Keywords

Public Health Glucose Catheter Small Intestine Glucose Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Digestive Disease Systems, Inc. 1981

Authors and Affiliations

  • V. Rayner
    • 1
  • T. E. C. Weekes
    • 1
  • J. B. Bruce
    • 1
  1. 1.Rowett Research InstituteAberdeenScotland

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