Digestive Diseases and Sciences

, Volume 37, Issue 6, pp 934–938 | Cite as

Mantle zone lymphoma of the colon simulating diffuse inflammatory bowel disease

Role of immunohistochemistry in establishing the diagnosis
  • J. Edward Mccullough
  • Chung H. Kim
  • Peter M. Banks
Case Report


We describe the first reported case of mantle zone lymphoma of the colon presenting as diffuse ileocolitis simulating severe inflammatory bowel disease. This case serves to illustrate the importance of immunohistochemistry in establishing the diagnosis of lymphoma in extranodal sites.

Key words

inflammatory bowel disease lymphoma colitis 


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  1. 1.
    Skinner JM: Gastrointestinal lymphoma. Pathology 17:193–203, 1985Google Scholar
  2. 2.
    Haber DA, Mayer RJ: Primary gastrointestinal lymphoma. Semin Oncol 15:154–169, 1988Google Scholar
  3. 3.
    Richards MA: Lymphoma of the colon and rectum. Postgrad Med J 62:615–620, 1986Google Scholar
  4. 4.
    Wychulis AR, Beahrs OH, Woolner LB: Malignant lymphoma of the colon. Arch Surg 93:215–225, 1966Google Scholar
  5. 5.
    Friedman HB, Silver G, Brown C: Lymphoma of the colon simulating ulcerative colitis. Am J Dig Dis 13:910–917, 1968Google Scholar
  6. 6.
    Sagar S, Selby P, Sloane J, McElwain TJ: Colorectal lymphoma simulating inflammatory colitis and diagnosed by immunohistochemistry. Postgrad Med J 62:51–53, 1986Google Scholar
  7. 7.
    Abulafi AM, Fiddian RV: Malignant lymphoma in ulcerative colitis. Dis Colon Rectum 33:615–618, 1990Google Scholar
  8. 8.
    Weir AB, Poon M-C, Groarke JF, Wilkerson JA: Lymphoma simulating Crohn's colitis. Dig Dis Sci 25:69–72, 1980Google Scholar
  9. 9.
    Gedgaudas-McClees RK, Maglinte DT: Aphthous lesions in nodular lymphoma of the colon. South Med J 79:907–908, 1986Google Scholar
  10. 10.
    Renton P, Blackshaw AJ: Colonic lymphoma complicating ulcerative colitis. Br J Surg 63:542–545, 1976Google Scholar
  11. 11.
    Weisenburger DD, Kim H, Rappaport H: Mantle-Zone lymphoma: A follicular varient of intermediate lymphocytic lymphoma. Cancer 49:1429–1438, 1982Google Scholar
  12. 12.
    Jaffe ES, Bookman MA, Longo DL: Lymphocytic lymphoma of intermediate differentiation-mantle zone lymphoma: A distinct subtype of B-cell lymphoma. Hum Pathol 18:877–880, 1987Google Scholar
  13. 13.
    Triozzi PL, Borowitz M, Gockerman J: Gastrointestinal involvement and multiple lymphomatous polyposis in mantle-zone lymphoma. J Clin Oncol 4:866–873, 1986Google Scholar
  14. 14.
    Dragosics B, Bauer P, Radaszkiewicz T: Primary gastrointestinal non-Hodgkin's lymphomas. Cancer 55:1060–1073, 1985Google Scholar
  15. 15.
    Jinnai D, Iwasa Z, Watahuki T: Malignant lymphoma of the large intestine. Jpn J Surg 13:331–336, 1983Google Scholar
  16. 16.
    O'Briain DS, Kennedy MJ, Daly PA, O'Brien AAJ, Tanner WA, Rogers P, Lawlor E: Multiple lymphomatous polyposis of the gastrointestinal tract: A clinicopathologically distinctive form of non-Hodgkin's lymphoma of B-cell centrocytic type. Am J Surg Pathol 13:691–699, 1989Google Scholar

Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • J. Edward Mccullough
    • 1
    • 2
  • Chung H. Kim
    • 1
    • 2
  • Peter M. Banks
    • 1
    • 2
  1. 1.Division of Gastroenterology and Internal MedicineMayo ClinicRochester
  2. 2.Department of Surgical PathologyMayo ClinicRochester

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