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Digestive Diseases and Sciences

, Volume 36, Issue 1, pp 103–107 | Cite as

Radiation-induced proctosigmoiditis

Prospective, randomized, double-blind controlled trial of oral sulfasalazine plus rectal steroids versus rectal sucralfate
  • R. Kochhar
  • F. Patel
  • S. C. Sharma
  • S. Ayyagari
  • R. Aggarwal
  • M. K. Goenka
  • B. D. Gupta
  • S. K. Mehta
Original Articles

Abstract

In a prospective study, 37 consecutive patients with radiation-induced proctosigmoiditis were randomized to receive a four-week course of either 3.0 g oral sulfasalazine plus 20 mg twice daily rectal prednisolone enemas (group I,N=18) or 2.0 g twice daily rectal sucralfate enemas plus oral placebo (group II,N=19). The two groups were comparable with respect to demographic features, duration of symptoms, and clinical and endoscopic staging of the disease. Fifteen patients in group I and 17 in group II completed the trial. At four weeks, both groups showed significant clinical improvement (P<0.01 for group I andP<0.001 for group II) and endoscopic healing (P<0.01 for group I andP<0.001 for group II). When the two groups were compared, sucralfate enemas showed a significantly better response as assessed clinically (P<0.05), although endoscopically the response was not statistically different (P>0.05). We conclude that both treatment regimens are effective in the management of radiation proctitis. Sucralfate enemas give a better clinical response, are tolerated better, and because of the lower cost should be the preferred mode of short-term treatment.

Key Words

radiation injury proctosigmoiditis sucralfate sulfasalazine prednisolone therapy 

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Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • R. Kochhar
    • 1
    • 2
  • F. Patel
    • 1
    • 2
  • S. C. Sharma
    • 1
    • 2
  • S. Ayyagari
    • 1
    • 2
  • R. Aggarwal
    • 1
    • 2
  • M. K. Goenka
    • 1
    • 2
  • B. D. Gupta
    • 1
    • 2
  • S. K. Mehta
    • 1
    • 2
  1. 1.Department of GastroenterologyPostgraduate Institute of Medical Education and ResearchChandigarhIndia
  2. 2.Department of RadiotherapyPostgraduate Institute of Medical Education and ResearchChandigarhIndia

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