Digestive Diseases and Sciences

, Volume 36, Issue 1, pp 25–28

Enhancement of antibiotic concentrations in gastric mucosa by H2-receptor antagonist

Implications for treatment ofHelicobacter pylori infections
  • T. Ulf Westblom
  • Dennis E. Duriex
Original Articles

DOI: 10.1007/BF01300082

Cite this article as:
Westblom, T.U. & Duriex, D.E. Digest Dis Sci (1991) 36: 25. doi:10.1007/BF01300082

Abstract

We measured the effects of cimetidine on antibiotic concentrations in the luminal portion of gastric mucosa. Guinea pigs were premedicated with cimetidine 4 mg/kg intramuscularly. Clindamycin, an antibiotic previously characterized under physiologic pH conditions, was administered intramuscularly and levels measured in serum and tissue using a high-pressure liquid chromatography (HPLC) technique. The luminal mucosa concentration of clindamycin at 1 hr (pH 5.9) was fivefold greater compared to the concentrations seen under physiologic (pH 2.0) conditions (81.5μg/g vs 15.9μg/g;P<0.05) and 10-fold greater at 2 hr (82.7μg/g vs 8.09μg/g;P<0.05). There was no difference in peak serum levels between the groups. The finding that an antibiotic with characteristics of a base is thus affected by a nonconservative acid inhibitor such as cimetidine supports the presence of an acidic storage pool as proposed by other investigators. H2-receptor antagonists may be useful therapeutic adjuncts inH. pylori infections by virtue of increasing gastric concentrations of antibiotics that behave as weak bases.

Key Words

gastric mucosa antibiotics H2-receptor antagonists gastric acid secretion Helicobacter pylori 

Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • T. Ulf Westblom
    • 1
    • 2
  • Dennis E. Duriex
    • 1
    • 2
  1. 1.Department of Medicine Division of Infectious DiseasesSt. Louis UniversitySt. Louis
  2. 2.Department of Medicine, Section of Infectious DiseasesMarshall UniversityHuntington

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