Myoelectrical activity and intraluminal flow in human sigmoid colon
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Myoelectric spike bursts were recorded in the sigmoid colon by means of an intraluminal silastic tube equipped with 3 Ag−AgCl ring electrodes fixed 15 cm apart on the tube that was introduced by flexible sigmoidoscopy. In six subjects, the tube was also equipped with three catheters whose tip opened 1 cm aborad from each electrode, for pressure recordings. In six other subjects, the tube was equipped with both electrodes and a catheter opening at the tip of the probe for infusing fluids at a rate of 12 ml/min into the colonic lumen. The fluid was collected with another tube inserted in the rectum and the volume was measured at 1-min intervals. Colonic spiking activity was made of rhythmic stationary bursts (RSB) and of sporadic bursts that were either propagating (SPB) or not propagating (SNPB). All sporadic bursts were associated with intraluminal pressure waves whose amplitude was significantly higher than that associated with rhythmic bursts. In the infusion experiments, the volume of fluid collected did not change significantly whether rhythmic bursts were present or not (3.9±1.7 ml/min and 3.3±1.9 ml/min respectively) (mean±sd). However, the volume was significantly higher when sporadic nonpropagating bursts were present (9.4±4.1 ml/min), and even higher when the sporadic bursts were propagating (21.6±8.8 ml/min). These results indicate that (1) the occurrence of sporadic bursts, particularly when propagating, is associated with intraluminal pressure waves that lead to significant propulsive movements; and (2) rhythmic bursts do not seem to be involved in colonic propulsive activity.
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- 1.Snape WJ, Matarazzo SA, Cohen S: Effect of eating and gastrointestinal hormones on human colonic myoelectric and motor activity. Gastroenterology 75:373–378, 1978Google Scholar
- 2.Bueno L: Patterns of colonic motility. Clin Res Rev 1(Suppl 1): 91–100, 1981Google Scholar
- 3.Sarna SK, Latimer P, Campbell D, Waterfall WE: Electrical and contractile activities of the human rectosigmoid. Gut 23:698–705, 1982Google Scholar
- 4.Couturier J, Roze C, Couturier-Turpin MH: Electromyography of the colonin situ: An experimental study in man and in the rabbit. Gastroenterology 56:317–322, 1969Google Scholar
- 5.Fleckenstein P: A probe for intraluminal recording of myoelectric activity from multiple sites in the human small intestine. Scand J Gastroenterol 73:767–770, 1978Google Scholar
- 6.Fioramonti J, Bueno L, Frexinos J: Sonde endoluminale pour l'exploration électromyographique de la motricité colique chez l'homme. Gastroenterol Clin Biol 4:546–550, 1980Google Scholar
- 7.Schang JC, Devroede G: Fasting and postprandial myoelectric spiking activity in the human sigmoid colon. Gastroenterology 85:1048–1053, 1983Google Scholar
- 8.Devroede G, Phillips SF: Studies on the perfusion technique for colonic absorption. Gastroenterology 56:92–100, 1969Google Scholar
- 9.Bueno L, Fioramonti J, Ruckebush Y, Frexinos J, Coulon P: Evaluation of colonic myoelectrical activity in health and functional disorders. Gut 21:480–489, 1980Google Scholar
- 10.Levitan R, Fordtran JS, Burrows BA, Ingelfinger FJ: Water and salt absorption in the human colon. J Clin Invest 41:1754–1759, 1962Google Scholar
- 11.Frexinos J, Bueno L, Fioramonti J: Dirunal changes in myoelectric spiking activity of the human colon. Gastroenterology 88:1104–1110, 1985Google Scholar