Digestive Diseases and Sciences

, Volume 36, Issue 4, pp 528–531 | Cite as

Kaposi's sarcoma of the colon in a young HIV-negative woman with Crohn's disease

  • T. Puy-Montbrun
  • F. Pigot
  • P. N. Vuong
  • R. Ganansia
  • J. Denis
Case Report


We report a case of isolated colonic Kaposi's sarcoma in a 36-year-old HIV-negative woman with refractory Crohn's disease of the colon and perineum following 11 months' treatment with azathioprine. The clinical features of this case are quite different from those classically described in Kaposi's sarcoma. Among the known risk factors, iatrogenic immunosuppression would appear to be the most probable.

Key Words

Crohn's disease azathioprine steroids Kaposi's sarcoma 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Kinlen LJ, Sheil AGR, Peto J, Doll R: A collaborative United Kingdom-Australian study of cancer in patients treated with immunosuppressive drugs. Br Med J 2:1461–1466, 1979Google Scholar
  2. 2.
    Penn I: Tumors of the immunocompromised patient. Annu Rev Med 39:63–73, 1988Google Scholar
  3. 3.
    Hutt MSR: Kaposi's sarcoma. Br Med Bull 40:355–358, 1984Google Scholar
  4. 4.
    Digiovanna JJ, Safai B. Kaposi's sarcoma. Retrospective study of 90 cases with particular emphasis on the familial occurrence, ethnic background and prevalence of other diseases. Am J Med 71:779–783, 1981Google Scholar
  5. 5.
    Shmueli D, Shapira Z, Yussima A, Nakache R, Ral Z, Shaharabani E: The incidence of Kaposi's sarcoma in renal transplant patients and its relation to immunosuppression. Transplant Proc 21:3209–3210, 1989Google Scholar
  6. 6.
    Van Den Berg F, Schiper M, Jiwa M, Rook R, Van Den Rijke F, Tigges B: Implausibility of an aetiological association between cytomegalovirus and Kaposi's sarcoma shown by four techniques. J Clin Pathol 42:128–131, 1989Google Scholar
  7. 7.
    Kinlen LJ: Incidence of cancer in rheumatoid arthritis and other disorders after immunosuppressive treatment. Am J Med 78(1A):44–49, 1985Google Scholar
  8. 8.
    Ventre JJ, Guillot M, Confavreux C, Evreux JC, Aimard G: Les effects indesirables de l'azathiorpine (Imurel R). A propos de 313 malades traités pour une sclérose en plaques. Thérapie 40:195–202, 1985Google Scholar
  9. 9.
    Gordon HW, Rywlin AM: Kaposi's sarcoma of the large intestine associated with ulcerative colitis. A hitherto unreported occurrence. Gastroenterology 50:248–253, 1966Google Scholar
  10. 10.
    Scaparro E, Borghi S, Rebora A: Kaposi's sarcoma after immunosuppressive therapy for bullous pemphigoid. Dermatologica 169:156–159, 1984Google Scholar
  11. 11.
    Thompson GB, Pemberton JM, Morris S, Bustamante MA, De Long B, Carpenter AH, Wright AJ: Kaposi's sarcoma of the colon in a young HIV negative man with chronic ulcerative colitis: Report of a case. Dis Col Rectum 32:73–76, 1989Google Scholar
  12. 12.
    Greenstein AJ, Sachar DB, Smith H, Janowitz HD, Aufses AH: A comparison of cancer risk in Crohn's disease and ulcerative colitis. Cancer 48:2742–2745, 1981Google Scholar
  13. 13.
    Martin ED, Bedossa P, Vaury P: Cancers et enterocolites cryptogénétiques chroniques. Gastroenterol Clin Biol 9:797–803, 1985Google Scholar
  14. 14.
    Koop HO, Holodnity M, List AF: Fulminant Kaposi's sarcoma complicating long-term corticosteroid therapy. Am J Med 83:787–789, 1987Google Scholar
  15. 15.
    Adlersberg R: Kaposi's sarcoma complicating ulcerative colitis: Report of a case. Am J Clin Pathol 54:143–146, 1970Google Scholar
  16. 16.
    Roth JA, Schell S, Panzarino S, Coronato A: Visceral Kaposi's sarcoma presenting as colitis. Am J Surg Pathol 2:202–214, 1978Google Scholar
  17. 17.
    Meltzer SJ, Rotterdam HZ, Korelitz BI: Kaposi's sarcoma occurring in association with ulcerative colitis. Am J Gastroenterol 82:378–381, 1987Google Scholar
  18. 18.
    Present DH, Meltzer SJ, Krumholz MP, Wolke A, Korelitz BI: 6-Mercaptopurine in the management of inflammatory bowel disease: Short- and long-term toxicity. Ann Intern Med 111:641–649, 1989Google Scholar
  19. 19.
    Lemann M, Bonhomme P, Bitoun A, Messing B, Modigliani R, Rambaud JC: Traitement par azathioprine ou 6-mercaptopurine de la maladie de Crohn; étude rétrospective de 98 cas. Gastroenterol Clin Biol 13:A 4 (abstract), 1989Google Scholar
  20. 20.
    Lesbordes JL, Martin PMV, Ravisse P, Georges-Courbot MC, Georges AJ: Clinical and histopathological aspects of Kaposi's sarcoma in Africa: Relationship with HIV serology. Ann Inst Pasteur Virol 139:197–203, 1988Google Scholar
  21. 21.
    Greenfield DI, Trinh P, Felenwider A, Barth WF, Kaposi's sarcoma in a patient with SLE. J Rheumatol 13:637–640, 1986Google Scholar
  22. 22.
    Schulhafer EP, Grossmanm E, Fagin G, Bell KE: Steroidinduced Kaposi's sarcoma in a patient with pre-AIDS. Am J Med 82:313–317, 1987Google Scholar
  23. 23.
    Barrison IG, Foster S, Harris JW, Pinching AJ, Walker JG: Upper gastrointestinal Kaposi's sarcoma in patients positive for HIV antibody without cutaneous disease, Br Med J 296:92–93, 1988Google Scholar
  24. 24.
    Blayney DW, Ito JI, Jensen FC: Spontaneous remission of kaposi's sarcoma in an HTL V-III-negative homosexual man Cancer 58:1583–1584, 1986Google Scholar
  25. 25.
    Erban SB, Sokas RK: Kaposi's sarcoma in an elderly man with Wegener's granulomatosis treated with cyclophosphamide and corticosteroids. Arch Intern Med 148:1201–1203, 1988Google Scholar
  26. 26.
    O'Donoghue DP, Dawson AR, Powell-Tuck J, Bown RL, Lennard-Jones JE: Double-blind withdrawal trial of azathioprine as maintenance treatment for Crohn's disease. Lancet 2:955–957, 1978Google Scholar
  27. 27.
    O'Brien JO, Bayless T: Immunosuppressive agents in the treatment of Crohn's disease including ileitis and ileocolitis. Gastroenterology 96: A370 (abstract), 1989Google Scholar
  28. 28.
    Korelitz BI, Present DH: Favorable effect of 6-mercaptopurine on fistulae of Crohn's disease. Dig Dis Sci 30:58–64, 1985Google Scholar

Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • T. Puy-Montbrun
    • 1
    • 2
  • F. Pigot
    • 1
    • 2
  • P. N. Vuong
    • 1
    • 2
  • R. Ganansia
    • 1
    • 2
  • J. Denis
    • 1
    • 2
  1. 1.Department of Colo-ProctologyHopital Léopold BellanParisFrance
  2. 2.Department of PathologyHopital Saint MichelParisFrance

Personalised recommendations