Digestive Diseases and Sciences

, Volume 36, Issue 4, pp 405–408 | Cite as

Inhibition of iron absorption by omeprazole in rat model

  • Jordan Golubov
  • Peter Flanagan
  • Paul Adams
Original Articles

Abstract

Since gastric acid is an important luminal factor in the absorption of non-heme iron, the effect of omeprazole on the absorption of iron in a rat model was studied. Iron absorption studies were performed on rats on a normal diet (N=42) and rats fed an iron-deficient diet (N=43) for three weeks. Rats were orally dosed with 40 μmol/kg of omeprazole or placebo daily for two days prior to iron absorption studies. Rats were orally dosed with 1 mmol of ferrous chloride, ferric chloride or food iron (dietary suspension) containing 11 μg of iron and labeled with 1 μCi of59Fe. Omeprazole-treated rats on the normal diet had no significant reduction in the absorption of ferric, ferrous, or food iron. In the rats on the iron-deficient diet, the absorption of ferrous iron decreased from 76±7.5% (mean±se) in control rats to 38±8.5% in the omeprazole-treated rats (P<0.003) and the absorption of food iron decreased from 65±7.5% in control rats to 37±6.5% in the omeprazole-treated rats (P<0.016). There was no significant reduction in the absorption of ferric iron. Omeprazole therapy is unlikely to be associated with significant iron malabsorption in normal patients but may reduce iron absorption in pathological states associated with increased iron absorption such as iron deficiency.

Key Words

iron absorption omeprazole iron deficiency 

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Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • Jordan Golubov
    • 1
  • Peter Flanagan
    • 1
  • Paul Adams
    • 1
  1. 1.Department of MedicineUniversity Hospital, University of Western OntarioLondonCanada
  2. 2.Department of GastroenterologyUniversity HospitalLondonCanada

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