Digestive Diseases and Sciences

, Volume 36, Issue 5, pp 634–640 | Cite as

PAF-induced bowel necrosis

Effects of vasodilators
  • Cheng Zhang
  • Wei Hsueh
Original Articles
Received:
Revised:
Accepted:

Abstract

Ischemic bowel necrosis in the rat is produced by injecting platelet-activating factor (PAF) intravenously. Since intestinal hypoperfusion is observed after PAF injection, we hypothesize that mesenteric vasoconstriction is the mechanism of bowel injury. We thus studied the effects of vasodilators in this model. We found that: (1) Phenoxybenzamine, prazosin, ICI 198615 (leukotriene antagonist) and PGE1 counteracted the PAF-induced mesenteric flow reduction and ameliorated the bowel injury. However, phenoxybenzamine and prazosin were relatively ineffective in correcting PAF-induced hypotension, showing that bowel injury can be prevented independently of the hypotensive state. (2) Nitroglycerin failed to prevent bowel injury, although it improved the mesenteric blood flow. Thus, in opposition to our initial hypothesis, correction of the mesenteric flow reduction induced by PAF does not always prevent intestinal necrosis. (3) Only phenoxybenzamine, prazosin, ICI 198615, and PGE1 ameliorated PAF-induced hemoconcentration and bowel injury. This suggests a correlation between vascular injury (expressed by “leaky” vessels and the consequent hemoconcentration) and bowel necrosis. (4) Although both nitroglycerin and hydralazine relax smooth muscle, hydralazine seemed to aggravate bowel necrosis. The mechanism remains unclear.

Key Words

PAF (platelet-activating factor) PAF-acether intestinal necrosis splanchnic circulation 
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Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • Cheng Zhang
    • 1
  • Wei Hsueh
    • 1
  1. 1.Department of Pathology, Children's Memorial HospitalNorthwestern University Medical SchoolChicago

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