Digestive Diseases and Sciences

, Volume 27, Issue 4, pp 333–340

High serum levels of secretory IgA in liver disease

Possible liver origin of the circulating secretory component
  • D. L. Delacroix
  • M. Reynaert
  • S. Pauwels
  • A. P. Geubel
  • J. P. Vaerman
Original Articles


Patients with liver disease frequently display unexplained elevations of serum secretory IgA (sIgA). The sIgA levels in various liver diseases were compared to various biochemical or clinical parameters. Patients with primary biliary cirrhosis, biliary tract obstruction, or acute hepatitis displayed highest sIgA levels. In chronic parenchymal liver disease sIgA levels correlated strongly with serum alkaline phosphatase (r=0.79), leucine aminopeptidase (r=0.83), and direct bilirubin levels (r=0.63), but not with prothrombin time, aminopyrine breath test, or presence of portacaval shunting. In acute hepatitis sIgA correlated best with serum glutamic oxaloacetic transaminase (r=0.69) but not with bilirubin; in four patients with fulminant hepatitis, sIgA fell rapidly together with all liver enzymes and prothrombin time; it rose quickly again in one patient when parenchymal regeneration occurred. These results suggest a hepatobiliary origin of the serum sIgA in liver disease. In acute hepatitis the persistence of hepatocytes seems necessary for maintaining high serum sIgA levels, suggesting a possible hepatocyte origin of the secretory component.


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Copyright information

© Digestive Disease Systems, Inc. 1982

Authors and Affiliations

  • D. L. Delacroix
    • 1
    • 2
  • M. Reynaert
    • 1
    • 2
  • S. Pauwels
    • 1
    • 2
  • A. P. Geubel
    • 1
    • 2
  • J. P. Vaerman
    • 1
    • 2
  1. 1.International Institute of Cellular and Molecular Pathology, Unit of Experimental MedicineUniversity of LouvainBrusselsBelgium
  2. 2.Intensive Care Unit, Gastroenterology UnitCliniques Universitaires St-LucBrusselsBelgium

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