Digestive Diseases and Sciences

, Volume 37, Issue 5, pp 784–790 | Cite as

Prospective study of clinical gallbladder disease and its association with obesity, physical activity, and other factors

  • Ikuko Kato
  • Abraham Nomura
  • Grant N. Stemmermann
  • Po-Huang Chyou
Original Articles


The association of anthropometric measurements, serum tests, and life-style factors with the risk of clinical gallbladder disease was investigated in a prospective study of 7831 American men of Japanese ancestry in Hawaii. After 152,831 person-years of observation, 471 incident cases of gallbladder disease were diagnosed by histology or radiology. There was an increase in risk of gallbladder disease with a progressive increase in body mass index, height, pack-years of cigarette smoking, and diastolic blood pressure. There was a decrease in risk with an increase in physical activity, after controlling for the effect of other variables. There was also an inverse association with total caloric intake that could be related to dietary restriction in obese subjects or to the limitations of the 24-hr diet history. Serum cholesterol levels and the intake of total fat were not related to clinical gallbladder disease in this cohort.

Key Words

gallbladder disease obesity physical activity smoking 


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Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • Ikuko Kato
    • 1
  • Abraham Nomura
    • 1
  • Grant N. Stemmermann
    • 1
  • Po-Huang Chyou
    • 1
  1. 1.Japan-Hawaii Cancer StudyKuakini Medical CenterHonolulu

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