Digestive Diseases and Sciences

, Volume 32, Issue 5, pp 481–486 | Cite as

Comparison of effects of ingested mediumand long-chain triglyceride on gallbladder volume and release of cholecystokinin and other gut peptides

  • P. E. T. Isaacs
  • S. Ladas
  • I. C. Forgacs
  • R. H. Dowling
  • S. V. Ellam
  • T. E. Adrian
  • S. R. Bloom
Original Articles


In a double-blind, crossover study of the effect of ingested medium-chain triglyceride (MCT) and long-chain triglyceride (LCT) in six normal subjects, the gallbladder did not contract after ingestion of MCT but instead had significantly increased in volume at 2 hr after the meal. Plasma cholecystokinin (CCK) increased after the MCT meal, but gastrin, motilin, pancreatic polypeptide (PP), and GIP were unaffected. The long-chain triglyceride meal evoked a brisk and sustained gallbladder contraction, higher levels of CCK, and a significant increase in plasma PP and GIP levels.

Key Words

gallbladder motility triglycerides cholecystokinin 


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Copyright information

© Plenum Publishing Corporation 1987

Authors and Affiliations

  • P. E. T. Isaacs
    • 1
    • 2
  • S. Ladas
    • 1
    • 2
  • I. C. Forgacs
    • 1
    • 2
  • R. H. Dowling
    • 1
    • 2
  • S. V. Ellam
    • 1
    • 2
  • T. E. Adrian
    • 1
    • 2
  • S. R. Bloom
    • 1
    • 2
  1. 1.Gastroenterology Unit, and Department of Clinical Physics and BioengineeringGuy's HospitalLondonU.K.
  2. 2.Department of MedicineHammersmith HospitalLondonU.K.

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