Digestive Diseases and Sciences

, Volume 26, Issue 12, pp 1069–1077

Hemodynamic and metabolic changes during stimulation of ileal motility

  • Kazimierz M. Walus
  • Joseph D. Fondacaro
  • Eugene D. Jacobson
Original Articles


Hemodynamic and metabolic responses of the mesenteric circulation were studied during infusion of agents known to stimulate intestinal motility. Agents were infused intraarterially in graded doses and included acetylcholine, angiotensin II, prostaglandin D2, prostaglandin F2-alpha, methionine-enkephalin, and morphine. Measurements were made of blood flow to the ileal portion of the small intestine, arteriovenous oxygen content difference, fractional distribution of radiolabeled microspheres to the muscularis, and intraluminal pressure. The clearance of86Rb was determined in some experiments. From these measurements we calculated oxygen consumption, fractional blood flow to the muscularis, permeability and surface area product (PS-product), and the mean motility index. All agents increased mean motility index to varying degrees. At comparable levels of increased mean motility index with each drug, there were variable degrees of increase or decrease or no change in the other parameters between drugs. Mesenteric hemodynamic and metabolic responses to these dissimilar stimuli of motor activity reflected mainly the vasoactive properties of each agent. This suggests that increased motor activity has little influence on the mesenteric circulation.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Haddy FJ, Chou C-C, Scott JB, Dabney JM: Intestinal vascular responses to naturally occurring vasoactive substances. Gastroenterology 52:444–451, 1967Google Scholar
  2. 2.
    Jacobson ED, Brobmann GF, Brecher GA: Intestinal motor activity and blood flow. Gastroenterology 58:575–579, 1970Google Scholar
  3. 3.
    Chou C-C, Grassmick B: Motility and blood flow distribution within the wall of the gastrointestinal tract. Am J Physiol 235:H34-H39, 1978Google Scholar
  4. 4.
    Sidky M, Bean JW: Influence of rhythmic and tonic contraction of intestinal muscle on blood flow and blood reservoir capacity in dog intestine. Am J Physiol 193:386–392, 1958Google Scholar
  5. 5.
    Geber WF: Intestinal blood flow—pressure responses during control and induced peristalsis. Arch Int Pharmacodyn 157:53–66, 1965Google Scholar
  6. 6.
    Semba T, Fujii K, Fujii Y: The influence of rhythmic and tonic contraction of the small intestine on blood flow through the intestinal segment. Jpn J Physiol 23:541–557, 1973Google Scholar
  7. 7.
    Semba T, Fujii K, Mizonishi T: Relation of intestinal motility to venous outflow and saturation of blood O2 through mesenteric blood vessels. Jpn J Physiol 23:541–557, 1973Google Scholar
  8. 8.
    Boatman DL, Brody MJ: Effects of acetylcholine on the intestinal vasculature of the dog. J Pharmacol Exp Ther 142:185–191, 1963Google Scholar
  9. 9.
    Brobmann GF, Jacobson ED, Brecher GA: Effects of distension and acetylcholine on intestinal blood flowin vivo. Angiologica 7:140–146, 1970Google Scholar
  10. 10.
    Kewenter J: Effects of graded acetylcholine infusions on intestinal motility, volume, and blood flow. Scand J Gastroenterol 6:435–440, 1971Google Scholar
  11. 11.
    Price WE, Shehadeh Z, Thompson GH, Underwood LD, Jacobson ED: Effects of acetylcholine on intestinal blood flow and motility. Am J Physiol 216:343–347, 1969Google Scholar
  12. 12.
    Shehadeh Z, Price WE, Jacobson ED: Effects of vasoactive agents on intestinal blood flow and motility in the dog. Am J Physiol 216:386–392, 1969Google Scholar
  13. 13.
    Zeigler MG, Barton RW, Swan KG: Mesenteric blood flow and small intestinal motility in the dog. Surgery 73:649–656, 1973Google Scholar
  14. 14.
    Shepherd AP, Burgar CG: A solid state arteriovenous oxygen difference analyzer for flowing whole blood. Am J Physiol 232:H437-H440, 1977Google Scholar
  15. 15.
    Hightower NC, Jr: Motor action of the small bowel.In Handbook of Physiology, Section 6: Alimentary Canal, Vol. IV, Motility, CF Code (ed) American Physiological Society, Washington, DC. 1968, pp 2001–2024Google Scholar
  16. 16.
    Weisbrodt NW, Wiley JN, Overholt BF, Bass P: A relation between gastroduodenal muscle contractions and gastric emptying. Gut 10:543–548, 1969Google Scholar
  17. 17.
    Renkin EM, Rosell S: The influence of sympathetic adrenergic vasoconstrictor nerves on transport of diffusible solutes from blood to tissues in skeletal muscle. Acta Physiol Scand 54:223–240, 1962Google Scholar
  18. 18.
    Pawlik W, Fondacaro JD, Jacobson ED: Metabolic hyperemia in the canine gut. Am J Physiol 2:G12-G17, 1980Google Scholar
  19. 19.
    Pawlik W, Mailman D, Shanbour LL, Jacobson ED: Dopamine effects on the intestinal circulation. Am Heart J 91:323–331, 1976Google Scholar
  20. 20.
    Hamberg M, Hedqvist P, Strandberg K, Svensson J, Samuelsson B: Prostaglandin endoperoxides. IV. Effects on smooth muscle. Life Sci 16:451–462, 1975Google Scholar
  21. 21.
    Bennett A, Posner J: Studies on prostaglandin antagonists. Br J Pharmacol 42:584–594, 1971Google Scholar
  22. 22.
    Khairallah PA, Page IH: Mechanism of action of angiotensin and bradykinin on smooth musclein situ. Am J Physiol 200:51–54, 1961Google Scholar
  23. 23.
    Hughes J, Smith TW, Kosterlitz HW, Fothergill LA, Morgan BA, Morris HR: Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature 258:577–579, 1975Google Scholar
  24. 24.
    Burks TF: Mediation by 5-hydroxytryptamine of morphine stimulant actions in dog intestine. J Pharmacol Exp Ther 185:530–539, 1973Google Scholar
  25. 25.
    Daniel EE, Sutherland WH, Bogoch A: Effects of morphine and other drugs on motility of the terminal ileum. Gastroenterology 36:510–522, 1959Google Scholar
  26. 26.
    Jaffe JH: Narcotic analgesics.In The Pharmacological Basis of Therapeutics, LS Goodman A Gilman (eds). Macmillan, London 1970, pp 237–275Google Scholar
  27. 27.
    Bean JW, Sidky MM: Intestinal blood flow as influenced by vascular and motor reactions to acetylcholine and carbon dioxide. Am J Physiol 194:512–518, 1958Google Scholar
  28. 28.
    Texter EC, Chou C-C, Merrill SL, Laureta HC, Frohlich ED: Direct effects of vasoactive agents on segmental resistance of the mesenteric and portal circulation. J Lab Clin Med 64:624–633, 1964Google Scholar
  29. 29.
    Kewenter J: The vagal control of the jejunal and ileal motility and blood flow. Acta Physiol Scand 65 (Suppl 251):1–68, 1965Google Scholar
  30. 30.
    Chapnick BM, Feigen LP, Hyman AL, Kadowitz PJ: Differential effects of prostaglandins in the mesenteric vascular bed. Am J Physiol 235:H326-H332, 1978Google Scholar
  31. 31.
    Feigen LP, Chapnick BM: Evidence for separate PGD2 and PGF2-alpha receptors in the canine mesenteric vascular bed. Prostaglandins 18:221–223, 1979Google Scholar
  32. 32.
    Angerio AD, Ramwell PW, Kot PA, Rose JC: Cardiovascular responses to PGD2 in the dog. Proc Soc Exp Biol Med 156:393–395, 1977Google Scholar
  33. 33.
    Wasserman MA, DuCharme DW, Griffin RL, DeGraaf GL, Robinson FG: Bronchopulmonary and cardiovascular effects of prostaglandin D2 in the dog. Prostaglandins 13:255–269, 1977Google Scholar
  34. 34.
    Polak JM, Bloom SR, Sullivan SN, Facer P, Pearse AGE: Enkephalin-like immunoreactivity in human gastrointestinal tract. Lancet 1:972–974, 1977Google Scholar
  35. 35.
    Leaman DM, Levenson L, Zelis R, Shiroff R: Effects of morphine on splanchnic blood flow. Br Heart J 40:569–571, 1978Google Scholar
  36. 36.
    Pawlik W, Walus K Fondacaro JD: Effects of methionine-enkephalin on intestinal circulation and oxygen consumption. Proc Soc Exp Biol Med 165:26–31, 1980Google Scholar
  37. 37.
    Pawlik W, Shepherd AP, Jacobson ED: Effects of vasoactive agents on intestinal oxygen consumption and blood flow in dogs. J Clin Invest 56:484–490, 1975Google Scholar
  38. 38.
    Barer GR: A comparison of the circulatory effects of angiotensin II, vasopressin and adrenaline in the anaesthetized cat. J Physiol (London) 156:49–66, 1961Google Scholar

Copyright information

© Digestive Disease Systems, Inc. 1981

Authors and Affiliations

  • Kazimierz M. Walus
    • 1
  • Joseph D. Fondacaro
    • 1
  • Eugene D. Jacobson
    • 1
  1. 1.Office of the Dean, Department of Physiology, College of MedicineUniversity of CincinnatiCincinnati

Personalised recommendations