Digestive Diseases and Sciences

, Volume 38, Issue 5, pp 870–876 | Cite as

Effect of erythromycin on interdigestive gastrointestinal contractile activity and plasma motilin concentration in humans

  • O. Kawamura
  • T. Sekiguchi
  • M. Kusano
  • T. Nishioka
  • Z. Itoh
Original Articles

Abstract

The effects of erythromycin (EM) on gastrointestinal contractile activity during the interdigestive period were investigated in seven healthy subjects using an infused catheter system, and the changes in the plasma motilin concentration were also determined. Graded EM doses (0.1–1.5 mg/kg) were administered intravenously over 5 min, usually during gastric phase I. EM induced interdigestive migrating contractions (IMCs). Their induction rate was low after low doses of EM, but gradually increased as the dose increased to reach, 71.4% at an EM dose of 0.375 mg/kg. Strong contractions, which were quite similar to phase III activity of the stomach but did not migrate or migrated incompletely to the duodenum, were observed at EM doses above 0.375 mg/kg. Therefore, the optimum dose of EM for inducing an IMC was established to be 0.375 mg/kg. In comparison with spontaneous IMCs, EM-induced IMCs had a significantly longer duration in the stomach and a significantly lower amplitude in the duodenum. These observations indicate that EM induced phase III activity more intensively in the stomach than in the duodenum. The plasma motilin concentration increased significantly during EM-induced IMCs, and this suggested a close relationship between this hormone and induction of the IMC. The increase in motilin levels was also observed of the strong gastric contractions which did not migrate or migrated incompletely to the duodenum. Therefore, it seems reasonable to suggest that motilin is involved in phase III activity of the stomach rather than in that of the duodenum.

Key Words

erythromycin interdigestive gastrointestinal contractile activity motilin infused catheter system interdigestive migrating contractions 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Szurszewski JH: A migrating electric complex of the canine small intestine. Am J Physiol 217:1757–1763, 1969Google Scholar
  2. 2.
    Vantrappen G, Janssens J, Peeters TL, Bloom SR, Christofides MD, Hellemans J: Motilin and the interdigestive migrating motor complex in man. Dig Dis Sci 24:497–500, 1979Google Scholar
  3. 3.
    Nisioka T, Sekiguchi T, Kogure M, Kusano M, Arai H, Katoh R, Okamura S, Matsuzaki T, Fukazawa H, Sugiyama T, Akiyama T, Ohwada T, Kobayashi S: A study on continuous simultaneous recordings of gastrointestinal motility and intraduodenal pH in healthy human subjects. Jpn J Gastroenterol 78:2065–2073, 1981 (in Japanese)Google Scholar
  4. 4.
    Itoh Z, Aizawa I, Sekiguchi T: The interdigestive migrating complex and its significance in man. Clin Gastroenterol 11:497–521, 1982Google Scholar
  5. 5.
    Itoh Z, Sekiguchi T: Interdigestive motor activity in health and disease. Scand J Gastroenterol 18(suppl 82):121–134, 1983Google Scholar
  6. 6.
    Itoh Z, Takeuchi S, Aizawa I, Mori K, Taminato T, Seino Y, Imura H, Yanaihara N: Changes in plasma motilin concentration and gastrointestinal contractile activity in conscious dogs. Am J Dig Dis 23:929–935, 1978Google Scholar
  7. 7.
    Bormans V, Peeters TL, Janssens J, Pearce D, Vandeweerd M, Vantrappen G: In man, only activity fronts that originate in the stomach correlate, with motilin peaks. Scand J Gastroenterol 22:781–784, 1987Google Scholar
  8. 8.
    You CH, Chey WY, Lee KY: Studies on plasma motilin concentration and interdigestive motility of the duodenum in humans. Gastroenterology 79:62–66, 1980Google Scholar
  9. 9.
    Peeters TL, Vantrappen G, Janssens J: Fasting plasma motilin levels are related to the interdigestive motility complex. Gastroenterology 79:716–719, 1980Google Scholar
  10. 10.
    Itoh Z, Nakaya M, Suzuki T, Arai H, Wakabayashi K: Erythromycin mimics exogenous motilin in gastrointestinal contractile activity in the dog. Am J Physiol 247:G688-G694, 1984Google Scholar
  11. 11.
    Tomomasa T, Kuroume T, Arai H, Wakabayashi K, Itoh Z: Erythromycin induces migrating motor complex in human gastrointestinal tract. Dig Dis Sci 31:157–161, 1986Google Scholar
  12. 12.
    Code CF, Marlett JA: The interdigestive myoelectric complex of the stomach and small bowel of dogs. J Physiol (London) 246:289–309, 1975Google Scholar
  13. 13.
    Nishioka T, Sekiguchi T, Kogure M, Kusano M, Kobayashi, S: The effects of trimebutine and metoclopramide on the gastroduodenal motility. Jpn J Smooth Muscle Res 18:105–113 1982 (in Japanese)Google Scholar
  14. 14.
    Nishioka T, Sekiguchi T, Machida M, Kusano M, Kogure M, Matsuzaki T, Katoh R, Horikoshi T, Fukagawa H, Tajima H, Toki M, Kikuchi K, Kawamura O, Mogi F, Sugiyama T, Ohwada T, Iizuka A, Kobayashi S: Effects of cisapride on lower esophageal sphincter pressure and gastroduodenal motor activity in man. Jpn J Smooth Muscle Res 22:103–112, 1986 (in Japanese)Google Scholar
  15. 15.
    Nishioka T, Sekiguchi T, Ohwada T: Effect of secretin on gastrointestinal motor activity—a study of initiation of duodenal secretin-induced migrating motor complexes. Jpn J Gastroenterol 77:1879–1889, 1980 (in Japanese)Google Scholar
  16. 16.
    Itoh Z, Suzuki T, Nakaya M, Inoue M, Mitsuhashi S: Gastrointestinal motor-stimulating activity of macrolide antibiotics and analysis of their side effects on the canine gut. Antimicrob Agents Chemother 26:863–869, 1984Google Scholar
  17. 17.
    Rees WDW, Leigh RJ, Christofides ND, Bloom SR, Turnberg LA: Interdigestive motor activity in patients with systemic sclerosis. Gastroenterology 83:575–580, 1982Google Scholar
  18. 18.
    Otterson MF, Sarna SK: Gastrointestinal motor effects of erythromycin. Am J Physiol 259:G355-G363, 1990Google Scholar
  19. 19.
    Thomas PA, Kelly KA, Go VLW: Does motilin regulate canine interdigestive gastric motility? Dig Dis Sci 24:577–582, 1979Google Scholar
  20. 20.
    Itoh Z, Honda R, Hiwatashi K, Takeuchi S, Aizawa I, Takayanagi R, Couch EF: Motilin-induced mechanical activity in the canine alimentary tract. Scand J Gastroenterol 11(suppl 39):93–110, 1976Google Scholar
  21. 21.
    Lee KY, Chang T-M, Chey WY: Effect of rabbit antimotilin serum on myoelectric activity and plasma motilin concentration in fasting dog. Am J Physiol 245:G547-G553, 1983Google Scholar
  22. 22.
    Sarna SK, Condon RE, Cowles V: Morphine versus motilin in the initiation of migrating myoelectric complex (MMC's). Am J Physiol 242:G588-G595, 1982Google Scholar
  23. 23.
    Thor P, Krol R, Konturek SJ, Coy DH, Schally AV: Effect of somatostatin on myoelectrical activity of small bowel. Am J Physiol 235:E249-E254, 1978Google Scholar
  24. 24.
    Owyang C, Achem-Karam SR, Vinik AI: Pancreatic polypeptide and intestinal migrating motor complex in humans. Gastroenterology 84:10–17, 1983Google Scholar
  25. 25.
    Lee KY, Chey WY, Tai H-H, Yajima H: Radioimmunoassay of motilin. Validation and studies on the relationship between motilin and interdigestive myoelectric activity of the duodenum of dog. Am J Dig Dis 23:789–795, 1978Google Scholar
  26. 26.
    Kondo Y, Torii K, Omura S, Itoh, Z: Erythromycin and its derivatives with motilin-like biological activities inhibit the specific binding, of125I-motilin to duodenal muscle. Biochem Biophys Res Commun 150:877–882, 1988Google Scholar
  27. 27.
    Peeters T, Matthijs G, Depoortere I, Cachet T, Hoogmartens J, Vantrappen G: Erythromycin is a motilin receptor agonist. Am J Physiol 20:G470-G474, 1989Google Scholar

Copyright information

© Plenum Publishing Corporation 1993

Authors and Affiliations

  • O. Kawamura
    • 1
    • 2
  • T. Sekiguchi
    • 1
    • 2
  • M. Kusano
    • 1
    • 2
  • T. Nishioka
    • 1
    • 2
  • Z. Itoh
    • 1
    • 2
  1. 1.First Department of Internal MedicineGunma University School of MedicineMaebashi, GunmaJapan
  2. 2.Institute of EndocrinologyGunma University School of MedicineMaebashiJapan

Personalised recommendations