Advertisement

Digestive Diseases and Sciences

, Volume 38, Issue 5, pp 824–831 | Cite as

Gastric acid inhibits antral phase III activity in duodenal ulcer patients

  • Motoyasu Kusano
  • Toshikazu Sekiguchi
  • Toshio Nishioka
  • Osamu Kawamura
  • Kazuma Kikuchi
  • Tsutomu Matsuzaki
  • Tsutomu Horikoshi
Original Articles

Abstract

Fourteen patients with duodenal ulcers and eight healthy volunteers were examined to measure interdigestive gastroduodenal motility and plasma motilin. In order to study the effects of gastric acid on the gastroduodenal motility, 20 mg of famotidine was administered intravenously. The motility index of the gastric antrum and the duodenum, as well as the pH in the duodenal bulb were calculated. The duodenal pH was significantly lower and the gastric motility index was significantly weaker before the duodenal interdigestive migrating complex (IMC) in the ulcer patients than in the controls. Motilin levels increased before the duodenal IMC and decreased afterwards in both groups. Famotidine significantly increased the duodenal pH and the gastric motility index before the IMC, but no changes in the motilin level were noted. We conclude that duodenal ulcer patients have duodenal hyperacidity that results from increased inflow from the antrum and antral hypomotility during the gastric IMC and that these changes are normalized by the administration of famotidine. These results suggest that gastric acid inhibits antral contraction during the gastric IMC.

Key Words

gastroduodenal motility motilin famotidine duodenal ulcer gastric acid interdigestive migrating complex 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Griffith GH, Owen GM, Kirkman S, Shields R: Measurement of rate of gastric emptying using chromium-51. Lancet 1:1244–1245, 1966Google Scholar
  2. 2.
    Heading RC, Tothill P, McLoughlin GP, Shearman DJC: Gastric emptying rate measurement in man. Gastroenterology 71:45–50, 1976Google Scholar
  3. 3.
    Harasawa S, Tani N, Suzuki S, Miwa M, Sakita R, Nomiyama T, Miwa T: Gastric emptying in normal subjects and patients with peptic ulcer. A study using the acetaminophen method. Gastroenterologia Jpn 14:1–10, 1979Google Scholar
  4. 4.
    Lam SK, Isenberg JI, Grossman MI, Lane WH, Hogan DL: Rapid gastric emptying in duodenal ulcer patients. Dig Dis Sci 27:598–604, 1982Google Scholar
  5. 5.
    Code CF, Marlett JA: The interdigestive myoelectric complex of the stomach and small bowel of dogs. J Physiol 246:289–309, 1975Google Scholar
  6. 6.
    Sekiguchi T, Nishioka T, Kogure M, Sugiyama M, Fukagawa H, Kobayashi S: Difference of interdigestive gastroduodenal motility and duodenal pH between duodenal and gastric ulcer patients. Jpn J Smooth Muscle Res 21(suppl):113–124, 1985Google Scholar
  7. 7.
    Hansen WE, Bertl S: Inhibition of acetylcholinesterases—a relevant side-effect of ranitidine? Z Gastroenterol 21:164–167, 1983Google Scholar
  8. 8.
    Bertaccini G, Coruzzi G: Cholinergic-like effects of the new histamine H2-receptor antagonist ranitidine. Agents Action 12:167–171, 1982Google Scholar
  9. 9.
    Jensen JG, Gugler R: Relevante Hemmung der Acetylcholinesterase durch H2-Rezeptorantagonisten? Z Gastroenterol 22:109–112, 1984Google Scholar
  10. 10.
    Yanaihara C, Sato H, Yanaihara N, Naruse S, Forssmann WG, Helmstaedter V, Fujita T, Yamaguchi K, Abe K: Motilin-, substance P- and somatostatin-like immunoreactivities in extracts from dog, tupaia and monkey brain and GI tract.In Gastrointestinal Hormones and Pathology of the Digestive System. M Grossman, V Speranza, N Basso, E Lezoche (eds). New York, Plenum Publishing, 1978, pp 269–283Google Scholar
  11. 11.
    Shima K, Shin S, Tanaka A, Hashimura E, Nishino T, Imagawa K, Kumahara Y, Yanaihara N: Heterogeneity of plasma motilin in patients with chronic renal failure. Horm Metab Res 12:328–331, 1980Google Scholar
  12. 12.
    Hutson WR, Roehrkasse RL, Wald A: Influence of gender and menopause on gastric emptying and motility. Gastroenterology 96:11–17, 1989Google Scholar
  13. 13.
    Aono M, Moriga M, Mizuta K, Narusawa H: Cholinergic effects of histamine-H2 receptor antagonists partly through inhibition of acetylcholinesterase. Gastroenterol Jpn 21:213–219, 1986Google Scholar
  14. 14.
    Takagi T, Takeda M, Maeno H: Effect of a new potent H2-blocker, 3-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]-thio]-N3-sulfamoylpropionamidine (YM-11170) on gastric secretion induced by histamine and food in conscious dogs. Arch Int Pharmacodyn 256:49–58, 1982Google Scholar
  15. 15.
    Lewis TD, Collins SM, Fox JE, Daniel EE: Initiation of duodenal acid-induced motor complexes. Gastroenterology 77:1217–1224, 1979Google Scholar
  16. 16.
    Allescher H-D, Daniel EE, Dent J, Fox JET, Kostolanska F: Neural reflex of the canine pylorus to intraduodenal acid infusion. Gastroenterology 96:18–28, 1989Google Scholar
  17. 17.
    Hayashi N, Mizumoto A, Kusano M, Sekiguchi T, Itoh Z: Inhibition of gastric acid secretion by H2 receptor antagonist normalizes interdigestive motor cycle in the stomach in dog and man. Gastroenterology 98:A56, 1990 (abstract)Google Scholar
  18. 18.
    Okajima M: Role of endogenous histamine in the control mechanism of postprandial gastric motility in dogs. Hiroshima Univ Med J 36:733–750, 1988Google Scholar

Copyright information

© Plenum Publishing Corporation 1993

Authors and Affiliations

  • Motoyasu Kusano
    • 1
  • Toshikazu Sekiguchi
    • 1
  • Toshio Nishioka
    • 1
  • Osamu Kawamura
    • 1
  • Kazuma Kikuchi
    • 1
  • Tsutomu Matsuzaki
    • 1
  • Tsutomu Horikoshi
    • 1
  1. 1.First Department of Internal MedicineGunma University, School of MedicineGunmaJapan

Personalised recommendations