Digestive Diseases and Sciences

, Volume 38, Issue 6, pp 1055–1061 | Cite as

Chronic bile diversion does not alter canine interdigestive myoelectric activity

  • Steven J. Hughes
  • Kevin E. Behrns
  • Michael G. Sarr
Original Articles
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Abstract

Previous studies have suggested that the cyclic entry of bile into the duodenum during fasting regulates interdigestive patterns of motility by releasing the putative regulatory hormone motilin. Our aim was to determine if cyclic secretion of bile into the duodenum regulates interdigestive myoelectric activity and plasma motilin concentrations. Six dogs were prepared with gastric and intestinal serosal electrodes. Myoelectric activity was measured during fasting and after a meal before and after reoperative translocation of the entrance of the bile duct to the mid-jejunum. The characteristics of the migrating myoelectric complex (MMC) and conversion to a postprandial pattern were similar before and after bile duct translocation. The period (112±5 vs 109±10 min;X±SEM), migration velocity of phase III through the duodenum (8.9±1.2 vs 6.8±0.5 cm/min), and duration of individual phases of the MMC in the stomach, duodenum, and jejunum were not altered significantly (eachP>0.05) by chronic diversion of bile from the duodenum. Plasma motilin concentrations were similar before and after bile duct translocation (P>0.05), continued to cycle temporally with the MMC, and peak concentrations occurred during phase III and were greater than during phase I and II (P<0.01). We conclude that the presence of bile in the lumen of the duodenum does not regulate interdigestive myoelectric patterns of the canine upper gut or the cyclic release of motilin.

Key Words

motility migrating motor complex interdigestive motility motilin biliary secretion postprandial motility 
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References

  1. 1.
    Szurszewski JH: A migrating electric complex of the canine small intestine. Am J Physiol 217:1757–1763, 1969Google Scholar
  2. 2.
    Sarna SK: Cyclic motor activity: Migrating motor complex: 1985. Gastroenterology 89:894–913, 1985Google Scholar
  3. 3.
    DeWever I, Eeckout C, Vantrappen G, Hellemans T: Disruptive effect of test meals on interdigestive MMC in dogs. Am J Physiol 235:E661-E665, 1978Google Scholar
  4. 4.
    Dalton RR, Zinsmeister AR, Sarr MG: Vagus-dependent disruption on interdigestive canine motility by gastric distention. Am J Physiol 262:G1097-G1103, 1992Google Scholar
  5. 5.
    Vantrappen GR, Peeters TL, Janssens J: The secretory component of the interdigestive migrating motor complex in man. Scand J Gastroenterol 14:663–667, 1979Google Scholar
  6. 6.
    Konturek SJ, Thor P: Relation between duodenal alkaline secretion and motility in fasted and sham-fed dogs. Am J Physiol 251:G591-G596, 1986Google Scholar
  7. 7.
    DiMagno EP, Hendricks JC, Go VLW, Dozois RR: Relationships among canine fasting pancreatic and biliary secretions, pancreatic duct pressure, and duodenal phase III motor activity—Boldyreff revisited. Dig Dis Sci 24:689–693, 1979Google Scholar
  8. 8.
    Keane FB, DiMagno EP, Dozois RR, Go VLW: Relationships among canine interdigestive exocrine pancreatic and biliary flow, duodenal motor activity, plasma pancreatic polypeptide, and motilin. Gastroenterology 78:310–316, 1980Google Scholar
  9. 9.
    Owyang C, Achem-Karam S, Funakoshi A, Vinik AI: Pancreato-biliary secretion stimulates motilin release and initiates the interdigestive migrating motor complex in man. Clin Res 30:287A, 1982Google Scholar
  10. 10.
    Owyang C, Funakoshi A, Vinik AI: Evidence for modulation of motilin secretion by pancreato-biliary juice in health and in chronic pancreatitis. J Clin Endocrinol Metab 57:1015–1020, 1983Google Scholar
  11. 11.
    Itoh Z, Honda R, Hiwatashi K, Takeuchi S, Aizawa I, Takayanagi R, Couch EF: Motilin-induced mechanical activity in the canine alimentary tract. Scand J Gastroenterol 11(suppl 39):93–110, 1976Google Scholar
  12. 12.
    Itoh Z, Takeuchi S, Aizawa I, Mori K, Taminato T, Seino Y, Imura H, Yanaihara N: Changes in plasma motilin concentration and gastrointestinal motor activity in conscious dogs. Am J Dig Dis 23:929–935, 1978Google Scholar
  13. 13.
    Thomas PA, Kelly KA, Go VLW: Does motilin regulate canine interdigestive gastric motility? Am J Dig Dis 24:577–582, 1979Google Scholar
  14. 14.
    Sarr MG, Kelly KA, Go VLW: Motilin regulation of canine interdigestive intestinal motility. Dig Dis Sci 28:249–256, 1983Google Scholar
  15. 15.
    Lee KY, Chang TM, Chey WY: Effect of rabbit antimotilin serum on myoelectric activity and plasma motilin concentration in fasting dog. Am J Physiol 245:G547-G553, 1983Google Scholar
  16. 16.
    Poitras P: Motilin is a digestive hormone in the dog. Gastroenterology 87:909–913, 1984Google Scholar
  17. 17.
    Tanaka M, Sarr MG: Role of the duodenum in the control of canine gastrointestinal motility. Gastroenterology 94:622–629, 1988Google Scholar
  18. 18.
    Malfertheiner P, Sarr MG, DiMagno EP: Role of the pancreas in the control of interdigestive gastrointestinal motility. Gastroenterology 92:200–205, 1989Google Scholar
  19. 19.
    Nilsson I, Svenberg T, Samuelsson K, Christofides N: Bile flow into the bowel is a signal for motilin release in man. Dig Dis Sci 29(suppl 8):A56, 1984Google Scholar
  20. 20.
    Ozeki K, Sarna SK, Condon RE: Bile acts at a porto-hepatic circulation site to initiate duodenal MMCs. Gastroenterology 100:A479, 1991Google Scholar
  21. 21.
    Code CF, Marlett JA: The interdigestive myo-electric complex of the stomach and small bowel of dogs. J Physiol 246:289–309, 1975Google Scholar
  22. 22.
    Takahashi I, Dodds WJ, Ammon H, Hogan WJ: Effect of intraduodenal bile on myoelectrical activity of the upper gastrointestinal tract and sphincter of Oddi.In Gastrointestinal Motility. C Roman (ed). Lancaster, MTP Press, 1984, pp 249–250Google Scholar
  23. 23.
    Nilsson BI, Svenberg T, Tollstrom T, Hellstrom PM, Samuelson K, Schnell P-O: Relationship between interdigestive gallbladder emptying, plasma motilin, and migrating motor complex in man. Acta Physiol Scand 139:55–61, 1990Google Scholar
  24. 24.
    Sarr MG, Duenes JA: Site of action of morphine sulfate and motilin in the induction of “premature” phase III-like activity in the canine gastrointestinal tract. Surgery 103:653–661, 1988Google Scholar
  25. 25.
    Polak JM, Pearse AGE, Heath CM: Complete identification of endocrine cells in the gastrointestinal tract using semithinthin sections to identify motilin cells in human and animal intestine. Gut 16:224–229, 1975Google Scholar
  26. 26.
    Romanski KW, Peeters TL, Vantrappen G: Are enterohepatic circulation and interdigestive motility related through motilin and PP secretion? Gastroenterology 88:1558, 1985Google Scholar
  27. 27.
    Scott RB: Effect of duodenal bile acid activity on fasting intestinal motor activity. Gastroenterology 88:1693, 1985Google Scholar
  28. 28.
    Scott RB: Effect of duodenal bile acid delivery on fasting intestinal motor activity. Am J Physiol 250:G836-G841, 1986Google Scholar
  29. 29.
    Hall KE, El-Sharkawy TY, Diamant NE: Vagal control of migrating motor complex in the dog. Am J Physiol 243:G276-G284, 1982Google Scholar
  30. 30.
    Hall KE, El-Sharkawy TY, Diamant NE: Vagal control of canine postprandial gastrointestinal motility. Am J Physiol 250:G501-G510, 1986Google Scholar
  31. 31.
    Van Lier Ribbink JA, Sarr MG, Tanaka M: Neural isolation of the entire canine stomachin vivo: Effects on motility. Am J Physiol 257:G30-G40, 1989Google Scholar
  32. 32.
    Spencer MP, Sarr MG, Hakim NS, Soper NJ: Interdigestive gastric motility patterns: The role of vagal and nonvagal extrinsic innervation. Surgery 106:185–194, 1989Google Scholar
  33. 33.
    Rees WDW, Malagelada J-R, Miller LJ, Go VLW: Human interdigestive and proprandial gastrointestinal motor and gastrointestinal hormone patterns. Dig Dis Sci 27:321–329, 1982Google Scholar
  34. 34.
    Kruis WA, Haddad A, Phillips SF: Chenodeoxycholic and ursodeoxycholic acids alter motility and fluid transit in the canine ileum. Digestion 34:185–195, 1986Google Scholar
  35. 35.
    Spiller RC, Trotman IF, Higgins BE, Ghatei MA, Grimble GK, Lee YC, Bloom SR, Misiewicz JJ, Silk DBA: The ileal brake: Inhibition of jejunal motility after ileal fat perfusion in man. Gut 25:365–374, 1984Google Scholar
  36. 36.
    Tohno T, Bentley KJ, Sandberg RJ, Sarr MG, DiMagno EP: Is postprandial regulation of amylase secretion (A) by carbohydrate (CHO) in the ileum a response to gastric emptying (GE) of solids or liquids? Pancreas 3:620, 1988Google Scholar

Copyright information

© Plenum Publishing Corporation 1993

Authors and Affiliations

  • Steven J. Hughes
    • 1
    • 2
  • Kevin E. Behrns
    • 1
    • 2
  • Michael G. Sarr
    • 1
    • 2
  1. 1.Gastroenterology Research UnitMayo Clinic and Mayo FoundationRochester
  2. 2.Department of SurgeryMayo Clinic and Mayo FoundationRochester

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