Digestive Diseases and Sciences

, Volume 28, Issue 3, pp 265–272 | Cite as

Morphologic and functional adaptations of large bowel after small-bowel resection in the rat

  • Ernest Urban
  • Peggy E. Starr
  • Anna M. Michel
Article
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Abstract

Seventy percent small bowel was resected in rats. Two and four weeks later transport of sodium, chloride, and water was examined in cecum and more distal large bowel (colon) using a well-establishedin vivo luminal perfusion technique. Sham-operated and unoperated rats served as controls. In cecum mucosa grew 29% by two weeks after resection but transport remained unchanged. There were no further adaptive changes by four weeks after resection. Unexpectedly, cecum of all rats secreted water and electrolytes. The mechanism remains unclear. In colon there were no adaptive changes by two weeks after resection but by four weeks colon mucosa increased 14% and luminal absorption increased proportionately. Separate studies showed hexose transport could not be induced in cecum or colon, although we have previously demonstrated its induction in contiguous remnant ileum.

Keywords

Sodium Chloride Luminal Small Bowel Hexose 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Digestive Disease Systems, Inc 1983

Authors and Affiliations

  • Ernest Urban
    • 1
    • 2
  • Peggy E. Starr
    • 1
    • 2
  • Anna M. Michel
    • 1
    • 2
  1. 1.Medical Service (111)Audie L. Murphy Veterans Administration HospitalSan Antonio
  2. 2.Department of MedicineThe University of Texas Health Science CenterSan Antonio

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