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Digestive Diseases and Sciences

, Volume 28, Issue 3, pp 216–224 | Cite as

Role of the liver in clearance and excretion of circulating carcinoembryonic antigen (CEA)

  • Peter Thomas
  • Norman Zamcheck
Article

Abstract

CEA is a glycoprotein with a molecular weight of 200,000 containing 55%–65% carbohydrate. The removal of only two sialic acid residues result in rapid uptake from the circulation by the liver and catabolism in the lysosomes. There is a receptor on the plasma membrane of the hepatocyte (hepatic binding protein) which recognizes galactosyl residues. About 70% of125I-labeled intact CEA is cleared by the liver in 1 hr. The exposure of terminal galactose residues by removing sialic acids determines the rate of clearance. CEA is probably initially taken up by Kupffer cells and transferred to hepatocytes. About 10% of CEA added to an isolated perfused liver appears in bile. Biliary duct obstruction and cholestasis may elevate plasma CEA levels due to detergent effects on the liver cell receptors.

Keywords

Galactose Sialic Acid Cell Receptor Cholestasis Kupffer Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Digestive Disease Systems, Inc 1983

Authors and Affiliations

  • Peter Thomas
    • 1
    • 2
  • Norman Zamcheck
    • 1
    • 2
  1. 1.Mallory Gastrointestinal Research Laboratory, Department of MedicineHarvard Medical SchoolBoston
  2. 2.Department of Pathology, Boston University School of MedicineBoston City HospitalBoston

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