Journal of Neural Transmission

, Volume 104, Issue 11–12, pp 1207–1214 | Cite as

The glutamate antagonist Riluzole suppresses intracortical facilitation

  • J. Liepert
  • P. Schwenkreis
  • M. Tegenthoff
  • J. -P. Malin
Basic Neurosciences and Genetics


The effect of the glutamate antagonist riluzole on excitatory and inhibitory phenomena in the human motor system was studied by transcranial magnetic stimulation (TMS) and peripheral electrical nerve stimulation. The motor threshold, the intracortical inhibition and intracortical facilitation as assessed by paired TMS, the cortical and peripheral silent periods, F wave amplitudes and F wave latencies were measured.

Riluzole suppressed the intracortical facilitation whereas other parameters remained unchanged, indicating that the neurotransmitter glutamate is mainly involved in facilitatory mechanisms in the motor system.


Transcranial magnetic stimulation riluzole glutamate intracortical inhibition intracortical facilitation silent period 


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Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • J. Liepert
    • 1
  • P. Schwenkreis
    • 1
  • M. Tegenthoff
    • 1
  • J. -P. Malin
    • 1
  1. 1.Department of NeurologyRuhr University BochumBochumFederal Republic of Germany

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