Journal of Neural Transmission

, Volume 103, Issue 8–9, pp 1053–1067

Simultaneously evoked primary and cognitive visual evoked potentials distinguish younger and older patients with Parkinson's disease

  • A. Antal
  • R. Pfeiffer
  • I. Bodis-Wollner
Parkinson's Disease and Allied Conditions

Summary

While it is known that both primary visual processes and visuocognitive responses are affected in Parkinson's Disease (PD), their relationship is not known. It is known that both of these measures can be affected by age per se. Our aims were to determine if in non-demented PD patients visual cognitive event-related potential (ERP) changes simply reflect abnormal primary visual processing and to determine the effects of age and disease on their relationship. In order to do so, we introduce a new normalizing procedure for visual ERPs. In addition to the latencies and amplitudes of P100, N140, P200, N200 and P300 components, the P300-P100 latency difference (termed “central processing time” —CPT) were measured. In order to avoid confounding factors of absolute amplitude differences due to say, generally low voltage recordings or poor primary visual responses, P300 responses normalized to P100 responses were also evaluated (P300/P100 amplitude ratio). Visual ERPs were obtained in an “oddball” paradigm in 20 non-demented patients with PD and 20 normal age-matched subjects. The stimuli were horizontal sinusoidal gratings differing only in spatial frequency (0.5 and 1 cycle/degree). While simple ERP latency criteria did not distinguish non-demented PD patients as a group from controls, when younger PD patients were compared to older PD patients and controls CPT acceleratedly increased in younger PD patients. The amplitudes of both N200 and P300 provided significant distinction between patient and control groups. The surprising result emerging from this study is that an individually normalized P300 amplitude provides significant distinction of younger PD patients from age matched normals.

Keywords

Parkinson's disease cognition age vision electrophysiology visual discrimination P100 P300 central processing time normalized ERP 

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References

  1. Amabile G, Fattaposta F, Pierelli F (1990) Evoked potentials in Parkinson's disease: sensory and cognitive aspects. A review. J Psychophysiol 4: 115–122Google Scholar
  2. Bobak P, Bodis-Wollner I, Guillory S (1987) The effect of blur and contrast on VEP latency: comparison between check and sinusoidal grating patterns. Electroencephalogr Clin Neurophysiol 87: 247–255Google Scholar
  3. Bobak P, Bodis-Wollner I, Guillory S, Anderson R (1989) Aging differentially delays visual evoked potentials to checks and gratings. Clin Vis Sci 4: 269–274Google Scholar
  4. Bodis-Wollner I (1985) Pattern evoked potential changes in Parkinson's disease are stimulus-dependent. Neurol 35: 1675–1676Google Scholar
  5. Bodis-Wollner I (1990) Visual deficits related to dopamine deficiency in experimental animals and Parkinson's disease patients. Trends Neurosci 13: 296–302Google Scholar
  6. Bodis-Wollner I, Yahr MD (1978) Measurements of visual evoked potentials in Parkinson's disease. Brain 101: 661–671Google Scholar
  7. Bodis-Wollner I, Pang S, Falk A, Ghilardi MF, Mylin L (1989) Vision and visual discrimination suffer in Parkinson's disease: evoked potential evidence. In: Bernardi G, Carpenter MB, Di Chiara G, Morelli M, Stanzione P (eds) The basal ganglia III. Plenum Press, New York, pp 743–750 (Adv Behav Biol 39)Google Scholar
  8. Bodis-Wollner I, Brannan JR, Nicoll J, Frkovic S, Mylin L (1992) A short latency cortical component of the foveal VEP is revealed by hemifield stimulation. Electroenephalogr Clin Neurophysiol 84: 201–208Google Scholar
  9. Bodis-Wollner I, Borod JC, Cicero B, Falk A, Haywood C, Mylin L, Raskin S, Sliwinsh M, Yahr M (1995) Modality dependent changes of event-related potentials correlate with specific cognitive dysfunction in non-demented patients with Parkinson's disease. J Neural Transm [PD Sect] 10: 62–69Google Scholar
  10. Campbell FW, Green DG (1965) Optical and retinal factors affecting visual resolution. J Physiol 181: 576–693Google Scholar
  11. Campbell FW, Gubisch RW (1966) Optical quality of the human eye. J Physiol 186: 558–578Google Scholar
  12. Czigler I, Csibra G (1990) Event-related potentials in a visual discrimination task: negative waves related to detection and attention. Psychophysiol 27: 669–676Google Scholar
  13. Donchin E, Ritter W, McCallum WC (1978) Cognitive psychophysiology: the endogenous components of the ERP. In: Callaway E, Tueting P, Koslow SH (eds) Even-trelated brain potentials in man. Academic Press, New York, pp 61–78Google Scholar
  14. Ebmeier KP, Potter DD, Cochrane RH, Crawford JR, Stewart L, Calder SA, Besson JA, Salzen EA (1992) Event related potentials, reaction time, and cognitive performance in idiopathic Parkinson's disease. Biol Psychol 33: 73–89Google Scholar
  15. Goodin DS, Aminoff MD (1987) Electrophysiological differences between demented and nondemented patients with Parkinson's disease. Ann Neurol 21: 90–94Google Scholar
  16. Goodin DS, Squires KS, Starr A (1978) Long latency event-related components of the auditory evoked potential in dementia. Brain 101: 635–648Google Scholar
  17. Hansch EC, Syndulko K, Cohen SN, Goldberg ZI, Potvin AR, Tourtellotte WW (1982) Cognition in Parkinson's disease: an event-related potential perspective. Ann Neurol 11: 599–607Google Scholar
  18. Higasa C, Nakashima K, Nishikawa S, Takahashi K, Yanagisawa M (1987) Event-related potential in Parkinson's disease. Rinsho Shin 27: 893–897Google Scholar
  19. O'Donell BF, Squires NK, Martz MJ, Chen JR, Phay AJ (1987) Evoked potential changes and neuropsychological performance in Parkinson's disease. Biol Psychol 24: 23–37Google Scholar
  20. Okuda B, Tachibana H, Kawabata K, Takeda M, Toda K, Sugita M (1992) Correlation of visual evoked potentials with dementia in Parkinson's disease. Nippon Ronen-Igakkai Zasshi 29: 475–479Google Scholar
  21. Onofrj MC, Fulgente T, Nobilio D, Bazzano S, Colamartino P (1991) Mapping of event-related potentials to auditory and visual odd-ball paradigms in controls. Eur Neurol 31: 220–228Google Scholar
  22. Pang S, Borod JC, Hernandez A, Bodis-Wollner I, Raskin S, Mylin L, Coscia L, Yahr MD (1990) The auditory P300 correlates with specific cognitive deficits in Parkinson's disease. J Neural Transm [PD Sect] 2: 249–264Google Scholar
  23. Picton TW (1992) The P300 wave of the event-related potentials. J Clin Neurophysiol 9: 456–479Google Scholar
  24. Pfefferbaum A, Ford J, Johnson R jr, Wenegrat B, Kopell BS (1983) Manipulation of P3 latency: speed vs. accuracy instructions. Electroencephalogr Clin Neurophysiol 55: 188–197Google Scholar
  25. Polich J, Ehlers CL, Otis S, Mandell AJ, Bloom FE (1986) P300 latency reflects the degree of cognitive decline in dementing illness. Electroencephalogr Clin Neurophysiol 63: 138–144Google Scholar
  26. Praser D, Findley L (1991) Dopaminergic induced changes in cognitive and motor processing in Parkinson's disease: an electrophysiological investigation. J Neurol Neurosurg Psychiatry 54: 603–609Google Scholar
  27. Stanzione P, Fattapposta F, Giunti P, D'Alessio C, Tagliati M, Affricano C, Amabile G (1991) P300 variations in parkinsonian patients before and during dopaminergic monotherapy: a suggested dopamine component of P300. Electroencephalogr Clin Neurophysiol 80: 446–453Google Scholar
  28. Starkstein SE, Esteguy M, Berthier ML, Garcia H, Leiguarda R (1989) Evoked potentials, reaction time and cognitive performance in on and off phases of Parkinson's disease. J Neurol Neurosurg Psychiatry 52: 338–340Google Scholar
  29. Tachibana H, Toda K, Sugita M, Konishi K, Matsunaga I (1991) Computed tomographic findings in relation to event-related potentials during visual discrimination tasks in patients with multiple cerebral infarcts. Int J Neurosci 59: 281–289Google Scholar
  30. Takeda M, Tachibana H, Okuda B, Kawabata K, Sugita M (1993) Event-related potential and visual evoked potential in patients with Parkinson's disease. Nippon Ronen Igakkai Zasshi 30: 363–368Google Scholar
  31. Toda K, Tachibana H, Sugita M, Konishi K (1993) P300 and reaction time in Parkinson's disease. J Geriatr Psych Neurol 6: 131–136Google Scholar

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • A. Antal
    • 1
    • 2
    • 3
  • R. Pfeiffer
    • 2
    • 4
  • I. Bodis-Wollner
    • 2
    • 3
  1. 1.Department of PhysiologyAlbert Szent-Gyorgyi Medical UniversitySzegedHungary
  2. 2.Department of Internal Medicine, Division of NeurologyUniversity of Nebraska Medical CenterOmaha
  3. 3.Department of NeurologySUNY, Health Science Center at BrooklynBrooklyn
  4. 4.Department of NeurologyUniversity of Tennessee MemphisMemphisUSA

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