101. Physiologie der Hämostase
Zusammenfassung
Die Verfügbarkeit des Hämostasepotential des Blutes garantiert die Aufrechterhaltung der Integrität der Gefäßwand sowie die Blutstillung bei Gefäßläsion und Gewebstrauma. Verschiedene Kompensationsmechanismen wie RES Clearance, Fibrinolysesystem und Inhibitoren der Gerinnung und Fibrinolyse gewährleisten die Aufrechterhaltung des hämostatischen Gleichgewichtes, dessen Störung entweder als Hypokoagulabilität oder als Hyperkoagulabilität imponieren kann. Die Rolle der Plättchen und der plasmatischen Faktoren sowie die Bedeutung der Fibrinstabilisierung und der lokalen Fibrinolyse werden in bezug auf die Blutstillung und die Wundheilung näher erörtert.
Physiology of the coagulation mechanism
Summary
The hemostatic potential is essentially dependent on maintenance of the integrity of the vessel wall and on hemostatis following vascular lesion and tissue damage. Several compensating mechanisms, such as RES clearance of activated products of coagulation, the fibrinolytic system, and inhibitors of coagulation and fibrinolysis, are involved in the physiological control of the hemostatic balance. Any disturbance of its equilibrium gives rise to hypocoagulability or hypercoagulable states. The role of platelets and plasmatic components and the significance of fibrin-stabilizing and fibrinolytic phenomena are discussed with reference to the hemostatic process itself and wound healing.
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