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Protoplasma

, Volume 105, Issue 1–2, pp 69–76 | Cite as

Influence of the antimicrotubule agent, mebendazole, on the secretory activity of intestinal cells ofAscaridia galli

  • Charlotte Atkinson
  • R. J. Newsam
  • K. Gull
Article

Summary

The anthelmintic compound mebendazole caused the disappearance of microtubules in the intestinal cells ofAscaridia galli. Electron microscopy revealed that soon after the microtubules disappeared there was an accumulation of secretory vesicles near the golgi areas. subsequently many of these vesicles aggregated forming dense large vesicles near the terminal web of the intestinal cells. This provides further evidence for the involvement of microtubules in the secretion of products from eukaryotic cells. It seems likely that inhibition of microtubule directed secretory functions in various cell types is an important function in the anthelmintic activity of the benzimidazole carbamates.

Keywords

Mebendazole Ascaridia Secretion Microtubules Anthelmintic 

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References

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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • Charlotte Atkinson
    • 1
  • R. J. Newsam
    • 1
  • K. Gull
    • 1
  1. 1.Biological LaboratoryUniversity of KentCanterbury, KentEngland

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