Phencyclidine-induced increases in striatal neuron firing in behaving rats: reversal by haloperidol and clozapine

  • I. M. White
  • G. S. Flory
  • K. C. Hooper
  • J. Speciale
  • D. A. Banks
  • G. V. Rebec
Full Papers


Amphetamine and related drugs of abuse facilitate dopamine transmission in the striatum. This action is believed to underlie the increase in firing of striatal motor-related neurons after amphetamine administration in behaving rats. The present study extended this electrophysiological investigation to phencyclidine (PCP), a nonamphetamine psychomotor stimulant that acts primarily as a noncompetitive antagonist of N-methyl-D-aspartate (NMDA) glutamate receptors. Like amphetamine, PCP (1.0, 2.5, or 5.0 mg/kg) increased the activity of striatal motor-related neurons concomitant with behavioral activation. These effects were blocked by subsequent administration of either 1.0 mg/kg haloperidol or 20.0 mg/kg clozapine, typical and atypical neuroleptics, respectively. Dizocilpine (MK-801), another noncompetitive NMDA antagonist, mimicked the effect of PCP. Collectively, these results indicate that amphetamine and NMDA antagonists exert comparable effects on striatal motor-related neurons, suggesting that the response of these cells to psychomotor stimulants is regulated by a dopaminergic-glutamatergic influence.


Striatum phencyclidine dizocilpine neuroleptics 


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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • I. M. White
    • 1
  • G. S. Flory
    • 1
  • K. C. Hooper
    • 1
  • J. Speciale
    • 1
  • D. A. Banks
    • 1
  • G. V. Rebec
    • 1
  1. 1.Program in Neural Science, Department of PsychologyIndiana UniversityBloomingtonUSA

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