Nitrite, nitrate and cGMP in the cerebrospinal fluid in degenerative neurologic diseases

  • M. Ikeda
  • I. Sato
  • T. Yuasa
  • T. Miyatake
  • S. Murota
Short Communications


To investigate whether nitric oxide (NO) plays a role in degenerative neurologic disease (DND), we measured nitrite, nitrate and cyclic GMP in cerebrospinal fluid (CSF) samples from patients with Parkinson's disease (PD), spinocerebellar ataxia (SCA) and amyotrophic lateral sclerosis (ALS). We found no significant change in CSF nitrite, nitrate or cyclic GMP in patients with any DND compared with control values. These results suggest that NO production is preserved in PD, SCA and ALS.


Amyotrophic lateral sclerosis cerebrospinal fluid cyclic GMP nitric oxide Parkinson's disease spinocerebellar ataxia 


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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • M. Ikeda
    • 1
    • 2
  • I. Sato
    • 1
  • T. Yuasa
    • 2
  • T. Miyatake
    • 3
  • S. Murota
    • 1
  1. 1.Department of Physiological Chemistry, Graduate SchoolTokyo Medical and Dental UniversityTokyo
  2. 2.Department of Neurology, School of MedicineTokyo Medical and Dental UniversityTokyo
  3. 3.Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

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