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Organization of the human serotonin transporter gene

  • K. -P. Lesch
  • U. Balling
  • J. Gross
  • K. Strauss
  • B. L. Wolozin
  • D. L. Murphy
  • P. Riederer
Rapid Communication

Summary

The gene encoding the human serotonin transporter (5-HTT) has been isolated and characterized. The human 5-HTT gene is composed of 14 exons spanning ∼ 31 kb. The sequence of all exons including adjacent intronic sequences and a tandem repeat DNA polymorphism (VNTR) has been determined and deposited in the EMBL/GenBank data base with the accession numbers X76753 to X76762. The characterization of 5-HTT gene will aid to advance molecular pharmacologic studies of 5-HT uptake regulation and facilitate investigations of its role in psychiatric disorders.

Keywords

Human serotonin transporter gene organization VNTR 

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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • K. -P. Lesch
    • 1
  • U. Balling
    • 1
  • J. Gross
    • 1
  • K. Strauss
    • 2
  • B. L. Wolozin
    • 2
  • D. L. Murphy
    • 2
  • P. Riederer
    • 1
  1. 1.Clinical Neurochemistry, Department of PsychiatryUniversity of WürzburgFederal Republic of Germany
  2. 2.LCS, NIMH, NIH Clinical CenterBethesdaUSA

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