Journal of Neural Transmission

, Volume 103, Issue 4, pp 503–507 | Cite as

Increased density of entorhinal glutamate-immunoreactive vertical fibers in schizophrenia

  • D. Longson
  • J. F. W. Deakin
  • F. M. Benes
Short Communication Biological Psychiatry

Summary

Gluatamtergic fibers have been immunocytochemically localized in the entorhinal cortex of postmortem schizophrenic brains. The density of small caliber vertical fibers was higher in schizophrenics than controls, with no significant increase in the number of large caliber fibers. Increased glutamatergic fiber density has been previously reported in the cingulate cortex. It is proposed that increases in glutamatergic fibers from the amygdala may be responsible for these changes and that they may play a central role in the pathophysiology of schizophrenia.

Keywords

Schizophrenia entorhinal glutamate 

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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • D. Longson
    • 1
  • J. F. W. Deakin
    • 2
  • F. M. Benes
    • 3
  1. 1.Laboratory for Structural NeuroscienceMcLean HospitalBelmontUSA
  2. 2.School of Psychiatry and Behavioural SciencesUniversity of ManchesterManchesterUK
  3. 3.Department of PsychiatryHarvard Medical SchoolBostonUSA

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