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Journal of Neural Transmission

, Volume 103, Issue 7, pp 765–776 | Cite as

Adaptive changes in the rat dopaminergic transmission following repeated lithium administration

  • M. Dziedzicka-Wasylewska
  • M. Maćkowiak
  • K. Fijaτ
  • K. Wędzony
Basic Neurosciences and Genetics

Summary

In the present study the alterations in the contents of dopamine (DA) and metabolites, as well as in the levels of mRNA coding for DA receptor D2, were determined in the rat striatum (STR) and nucleus accumbens septi (NAS), in correlation with the duration of lithium administration. Single or subchronic (3 days) administration of lithium produced less consistent effects as far as the levels of DA and metabolites are concerned; however, following 7 or 14 days of lithium administration, the DA release from terminals was significantly attenuated and the effect was more pronounced in NAS. After the same time of treatment, the increase in the levels of mRNA coding for the D2 receptor was increased; this might be interpreted as an adaptive change to the decreased dopaminergic transmission following the prolonged administration of lithium.

Keywords

Lithium dopamine striatum nucleus accumbens mRNA D2 rat 

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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • M. Dziedzicka-Wasylewska
    • 1
  • M. Maćkowiak
    • 1
  • K. Fijaτ
    • 1
  • K. Wędzony
    • 1
  1. 1.Institute of PharmacologyPolish Academy of SciencesKrakówPoland

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