Advertisement

Journal of Neural Transmission

, Volume 103, Issue 12, pp 1457–1462 | Cite as

CSF inositol does not predict antidepressant response to inositol

  • J. Levine
  • L. Kurtzman
  • A. Rapoport
  • J. Zimmerman
  • Y. Bersudsky
  • J. Shapiro
  • R. H. Belmaker
  • G. Agam
Short Communication

Summary

CSF inositol was reported to be reduced in depression and inositol has been reported to be effective in treatment of depression. We studied CSF inositol in 18 drug-free depressed patients and 36 normal controls; the depressed patients then participated in an open trial of 18 gm daily inositol treatment for 4 weeks. There was no difference in pre-treatment CSF inositol between depressed patients and controls. CSF inositol levels did not predict response on the Hamilton Depression Scale to 4 weeks of inositol treatment.

Keywords

Depression inositol CSF 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Agam G, Shapiro J, Bersudsky Y, Kofman O, Belmaker RH (1994) Effect of high-dose peripheral inositol: brain inositol levels and prevention of behavioral changes due to inositol depletion. Pharmacol Biochem Behav 49: 341–343Google Scholar
  2. Barkai IA, Dunner DL, Gross HA, Mayo P, Fieve RR (1978) Reduced myo-inositol levels in cerebrospinal fluid from patients with affective disorder. Biol Psychiatry 13: 65–72Google Scholar
  3. Bersudsky Y, Shapiro J, Agam G, Kofman O, Belmaker RH (1994) Behavioral evidence for the existence of two pools of cellular inositol. Eur Neuropsychopharmacol 4: 463–467Google Scholar
  4. Kofman O, Belmaker RH (1993) Biochemical, behavioral and clinical studies of the role of inositol in lithium treatment and depression. Biol Psychiatry 34: 839–852Google Scholar
  5. Levine J, Gonzalves M, Barbam I, Stier S, Elizur A, Kofman O, Belmaker RH (1993a) Inositol 6gm daily may be effective in depression but not in schizophrenia. Hum Psychopharmacol 8: 49–53Google Scholar
  6. Levine J, Rapaport A, Lev L, Bersudsky Y, Kofman O, Belmaker RH, Shapiro J, Agam G (1993b) Inositol treatment raises CSF inositol levels. Brain Res 627: 168–170Google Scholar
  7. Levine J, Goldberger I, Rapaport A, Schwartz M, Schieids C, Elizur A, Belmaker RH, Shapiro J, Agam G (1994) CSF inositol levels in schizophrenia are unchanged and inositol is not therapeutic in anergic schizophrenia. Eur Neuropsychopharmacol 4: 487–490Google Scholar
  8. Levine J, Barak Y, Gonsalves M, Szor H, Elizur A, Kofman O, Belmaker RH (1995) A double-blind controlled trial of inositol treatment of depression. Am J Psychiatry 152: 792–794Google Scholar
  9. Potter WZ, Manji (1993) Are CSF monoamine metabolites worth measuring? Arch Gen Psychiatry 50: 563–565Google Scholar
  10. Rahman S, Neuman RS (1993) Myo-inositol reduces serotonin (5-HT2) receptor induced homologous and hetrologous desensitization. Brain Res 631: 349–351Google Scholar
  11. Shetty HM, Schapiro MB, Holloway HW, Rapoport SI (1995) Polyol profiles in Down syndrome: myo-inositol specifically, is elevated in the cerebrospinal fluid. Clin Invest 95: 542–546Google Scholar
  12. Shimon H, Agam G, Belmaker RH, Hyde T, Kleinman JE (1996) Reduced inositol levels in frontal cortex of post-mortem brain from bipolar patients and suicides. Am J Psychiatry (submitted)Google Scholar

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • J. Levine
    • 1
  • L. Kurtzman
    • 1
  • A. Rapoport
    • 1
  • J. Zimmerman
    • 1
  • Y. Bersudsky
    • 1
  • J. Shapiro
    • 1
  • R. H. Belmaker
    • 1
  • G. Agam
    • 1
  1. 1.Ministry of Health Mental Health Center, Faculty of Health SciencesBen Gurion University of the NegevBeershevaIsrael

Personalised recommendations