Journal of Neural Transmission

, Volume 103, Issue 10, pp 1221–1229

Additive effects, but no synergistic interaction of stressful life-events and genetic loading in affective disorders

  • J. Fritze
  • B. Schneider
  • K. Maurer
Biological Psychiatry

DOI: 10.1007/BF01271207

Cite this article as:
Fritze, J., Schneider, B. & Maurer, K. J. Neural Transmission (1996) 103: 1221. doi:10.1007/BF01271207

Summary

Life-event research as well as neurobiological findings point to the relevance of adverse stress for the pathogenesis of affective disorders. The well established genetic root might be related to the sensitivity to stress. In concordance, recent studies showed a synergistic interaction between genetic loading and life-events concerning the precipitation of depression, i.e. there might exist a genetic sensitization to the adverse effects of stressors. The present investigation, using information extracted from 877 case records, did not reveal a synergistic interaction concerning the age at onset and the mean frequency and duration of episodes.

Keywords

Depression genetics life-event stress 

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • J. Fritze
    • 1
  • B. Schneider
    • 1
  • K. Maurer
    • 1
  1. 1.Department of PsychiatryUniversity of Frankfurt/MainFederal Republic of Germany

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