Regulatory functions of the coronary endothelium
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Abstract
In this brief review three functions of the coronary endothelium are surveyed: (a) its barrier and exchange function, (b) the prevention of coagulation and platelet aggregation, and (c) its role in vasoregulation. Impairment of these functions can occur in ischemia, hypertension, arteriosclerosis and inflammation. (Mol Cell Biochem116: 163–169, 1992)
Key words
endothelium permeability vasoregulation antithrombotic arteriosclerosisPreview
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- 1.Curry FE: Determinants of capillary permeability: a review of mechanisms based on single capillary studies in the frog. Cite Res 59:367–380,1986Google Scholar
- 2.Renkin EM: Capillary transport of macromolecules: pores and other endothelial pathways. J Appl Physiol 58: 315–325, 1985Google Scholar
- 3.Blanchette-Mackie EJ, Scow RO: Lipolysis and lamellar structures in white adipose tissue of young rats: lipid movement in membranes. J Ultrastruc Res 77: 295–318, 1981Google Scholar
- 4.Wysolmerski RB, Lagunoff D: Involvement of myosin lightchain kinase in endothelial cell retraction. Proc Natl Acad Sci USA 87: 16–20, 1990Google Scholar
- 5.Schnittler H-J, Wilke A, Gress T, Suttorp N, Drenckhahn D: Role of actin and myosin in the control of paracellular permeability in pig, rat and human vascular endothelium. J Physiol 431: 379–401,1990Google Scholar
- 6.He P, Pagakis SN, Curry FE: Measurement of cytoplasmic calcium in single microvessels with increased permeability. Am J Physiol 258: H1366-H1374, 1990Google Scholar
- 7.Grega GJ, Persson CGA, Svensjö E: Endothelial cell reactions to inflammatory mediators assessedin vivo by fluid and soluteflux analysis. In: US Ryan (ed.) Endothelial Cells Vol III. CRC Press Incorporated, Boca Raton, 1988, pp 103–119Google Scholar
- 8.Stelzner TJ, Weil JV, O'Brien RF: Role of cyclic adenosine monophosphate in the induction of endothelial barrier properties. J Cell Physiol 139: 157–166, 1989Google Scholar
- 9.Langeler EG, Van Hinsbergh VWM: Norepinephrine and iloprost improve barrier function of human endothelial cell monolayers: role of CAMP. Am J Physiol 260: C1052-C1059, 1991Google Scholar
- 10.Majno G, Shea SM, Leventhal M: Endothelial contraction induced by histamine-type mediators. An electron microscopic study. J Cell Biol 42: 647–672, 1969Google Scholar
- 11.Palade GE: The microvascular endothelium revisited. In: N Simionescu and M Simionescu (eds) Endothelial Cell Biology in Health and Disease. Plenum Publishing Corporation, New York, 1988, pp 3–21Google Scholar
- 12.Predescu D, Simionescu M, Simionescu N, Palade GE: Binding and transcytosis of glycoalbumin by the microvascular endothelium of the murine myocardium: evidence that glycoalbumin behaves as a bifunctional ligand. J Cell Biol 107: 1729–1738,1988Google Scholar
- 13.Frøkjær-Jensen J: Three-dimensional organization of plasmalemmal vesicles in endothelial cells. An analysis by serial sectioning of frog mesenteric capillaries. J Ultrastruct Res 73: 9–20,1980Google Scholar
- 14.Bundgaard M, Hageman P, Crone C: The three-dimensional organization of plasmalemmal vesicular profiles in the endothelium of rat heart capillaries. Microvasc Res 25: 358–368, 1983Google Scholar
- 15.Cornford EM: The blood-brain barrier, a dynamic regulatory interface. Mol Physiol 7: 219–260, 1985Google Scholar
- 16.Milici AJ, Watrous NE, Stukenbrok H, Palade GE: Transcytosis of albumin in capillary endothelium. J Cell Biol 105: 2603–2612, 1987Google Scholar
- 17.Vasile E, Simionescu M, Simionescu N: Visualization of the binding, endocytosis, and transcytosis of low-density lipoprotein in the arterial endotheliumin situ. J Cell Biol 96: 1677–1689, 1983Google Scholar
- 18.Wiklund O, Carew TE, Steinberg D: Role of the low density lipoprotein receptor in penetration of low density lipoprotein into rabbit aortic wall. Arteriosclerosis 5: 135–141, 1985Google Scholar
- 19.Langeler EG, Snelting-Havinga I, Van Hinsbergh VWM: Passage of low density lipoproteins through monolayers of human arterial endothelial cells. Effects of vasoactive substances in anin vitro model. Arteriosclerosis 9: 550–559, 1989Google Scholar
- 20.Rutledge JC, Curry FE, Lenz JF, Davis PA: Low density lipoprotein transport across a microvascular endothelial barrier after permeability is increased. Circ Res 66: 486–495, 1990Google Scholar
- 21.Bremmelgaard A, Stender S, Lorentzen J, Kjeldsen K:In vivo flux of plasma cholesterol into human abdominal aorta with advanced atherosclerosis. Arteriosclerosis 6: 442–452, 1986Google Scholar
- 22.Stemerman MB: Effects of moderate hypercholesterolemia on rabbit endothelium. Arteriosclerosis 1: 25–32, 1981Google Scholar
- 23.Colman RW, Hirsch J, Marder VV, et al.: Hemostasis and Thrombosis: Basic Principles and Clinical Practice. Lippincott, Philadelphia, 1987Google Scholar
- 24.Harker LA: Endothelium and hemostasis. In: US Ryan (ed.) Endothelial Cells, Vol 1. CRC Press, Boca Raton, 1988, pp 167–177Google Scholar
- 25.Mann KG, Jenny RJ, Krishnaswamy S: Cofactor proteins in the assembly and expression of blood clotting enzyme complexes. Ann Rev Biochem 57: 915–956,1988Google Scholar
- 26.Preissner KT: Anticoagulant potential of endothelial cell membrane components. Haemostasis 18: 271–306, 1988Google Scholar
- 27.Esmon CT: The role of protein C and thrombomodulin in the regulation of blood coagulation. J Biol Chem 264: 4743–4746, 1989Google Scholar
- 28.Rapaport SI: The extrinsic pathway inhibitor: a regulator of tissue factor-dependent blood coagulation. Thromb Haemostas 66: 6–15, 1991Google Scholar
- 29.Sandset PM, Warn-Cramer BJ, Rao LVM, Maki SL, Rapaport DI: Depletion of extrinsic pathway inhibitor (EPI) sensitizes rabbits to disseminated intravascular coagulation induced with tissue factor: evidence supporting a physiologic role for EPI as a natural anticoagulant. Proc Natl Acad Sci USA 88: 708–712,1991Google Scholar
- 30.Sixma JJ: Platelet adhesion in health and disease. In: M Verstraete, J Vermylen, R Lijnen and J Arnout (eds) Thrombosis and Haemostasis 1987. Leuven University Press, Leuven, 1987, pp 127–146Google Scholar
- 31.Moncada S, Palmer RMJ, Higgs EA: Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43: 109–142,1991Google Scholar
- 32.Gordon JL: Extracellular ATP: effects, sources and fate. Biochem J 233: 309–319, 1986Google Scholar
- 33.Bachmann F: Fibrinolysis. In: M Verstraete, J Vermylen, R Lijnen and J Arnout (eds) Thrombosis and Haemostasis 1987. Leuven University Press, Leuven, 1987, pp 227–265Google Scholar
- 34.Wun T-C, Capuano A: Spontaneous fibrinolysis in whole human plasma: identification of tissue activator-related protein as the major plasminogen activator causing spontaneous activityin vitro. J Biol Chem 260: 5061–5066, 1985Google Scholar
- 35.Kristensen P, Larsson L-I, Nielsen LS, Grøndahl-Hansen J, Andreasen PA, Danß K: Human endothelial cells contain one type of plasminogen activator. FEBS Lett 168: 33–37, 1984Google Scholar
- 36.Emeis JJ: Mechanisms involved in short-term changes in blood levels of t-PA. In: C Kluft (ed.) Tissue-Type Plasminogen Activator (t-PA): Physiological and Clinical Aspects, Vol II. CRC Press, Boca Raton, 1988, pp 21–35Google Scholar
- 37.Van Hinsbergh VWM, Kooistra T, Emeis JJ, Koolwijk P: Regulation of plasminogen activator production by endothelial cells: role in fibrinolysis and local proteolysis. Int J Radiat Biol 60: 261–272, 1991Google Scholar
- 38.Erdos EG: Angiotensin-I converting enzyme. Circ Res 36: 247–255,1975Google Scholar
- 39.Haddock RC, Mack P, Fogerty FJ, Lewis Baenziger N: Role of receptors in metabolic interaction of histamine with human vascular endothelial cells and skin fibroblasts. J Biol Chem 262: 10220–10228,1987Google Scholar
- 40.Furchgott RF, Zawadzki JV: The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288: 373–376, 1980Google Scholar
- 41.Bassenge E, Busse R: Endothelial modulation of coronary tone. Progr Cardiovasc Disease 30: 349–380, 1988Google Scholar
- 42.Furchgott RF, Vanhoutte PM: Endothelium-derived relaxing and contracting factors. FASEB J 3: 2007–2018, 1989Google Scholar
- 43.Rubanyi GM: Endothelium-derived relaxing and contracting factors. J Cell Biochem 46: 27–36, 1991Google Scholar
- 44.Meyers PR, Minor RL Jr, Guerra R Jr, Bates JN, Harrison DG: Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide. Nature 345: 161–163, 1990Google Scholar
- 45.Radomski MW, Palmer RMJ, Moncada S: Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells. Proc Natl Acad Sci USA 87: 10043–10047, 1990Google Scholar
- 46.Gerritsen ME: Functional heterogeneity of vascular endothelial cells. Biochem Pharmacol 36: 2701–2711, 1987Google Scholar
- 47.Dejana E, Breviario F, Balconi G, Rossi V, Remuzzi G, de Gaetano G, Mantovani A: Stimulation of prostacyclin synthesis in vascular cells by mononuclear cell products. Blood 64: 1280–1283, 1984Google Scholar
- 48.Maier JA, Hla T, Maciag T: Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells. J Biol Chem 265: 10805–10808, 1990Google Scholar
- 49.Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T: A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332: 411–415, 1988Google Scholar
- 50.Nunez DJR, Brown MJ, Davenport AP, Neylon CB, Schofield JP, Wyse RK: Endothelin-1 mRNA is widely expressed in porcine and human tissues. J Clin Invest 85: 1537–1541, 1990Google Scholar
- 51.Holtz J, Giesler M, Bassenge E: Two dilatory mechanisms of anti-anginal drugs on epicardial coronary arteriesin vivo: indirect, flow-dependent, endothelium-mediated dilation and direct smooth muscle relaxation. Z Kardiol 72: 98–106, 1983Google Scholar
- 52.Pohl U, Holtz J, Busse R, et al.: Crucial role of endothelium in the vasodilator reponse to increased flowin vivo. Hypertension 7:37–44,1986Google Scholar
- 53.Lansman JB, Hallam TJ, Rink TJ: Single stretch-activated ion channels in vascular endothelial cells as mechanotransducers? Nature 325: 811–813, 1987Google Scholar
- 54.Busse R, Förstermann U, Matsuda H, Pohl U: The role of prostaglandins in the endothelium-mediated vasodilatory response to hypoxia. Pflügers Arch 401: 77–83, 1984Google Scholar
- 55.Ogawa S, Gerlach H, Esposito C, Pasagian-Macaulay A, Brett J, Stern D: Hypoxia modulates the barrier and coagulant function of cultured bovine endothelium. Increased monolayer perme ability and induction of procoagulant properties. J Clin Invest 85: 1090–1098,1990Google Scholar
- 56.Cybulsky MI, Gimbrone Jr MA: Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science 251: 788–791, 1991Google Scholar
- 57.Ludmer PL, Selwyn AP, Shook TL, Wayne RR, Mudge GH, Alexander RW, Ganz P: Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. New Engl J Med 315: 1046–1051, 1986Google Scholar
- 58.Bossaller C, Habib GB, Yamamoto H, Williams C, Wells S, Henry PD: Impaired muscarinic endothelium-dependent relaxation and cyclic guanosine 5′-monophosphate formation in atherosclerotic human coronary artery and rabbit aorta. J Clin Invest 79:170–174,1987Google Scholar
- 59.Shimokawa H, Flavahan NA, Vanhoutte PM: Natural course of the impairment of endothelium-dependent relaxations after balloon endothelium removal in porcine coronary arteries. Possible dysfunction of a pertussis toxin-sensitive G-protein. Circ Res 65: 740–753,1989Google Scholar
- 60.Shimokawa H, Vanhoutte PM: Dietary cod-liver oil improves endothelium-dependent responses in hypercholesterolemic and atherosclerotic porcine coronary arteries. Circulation 78: 1421–1430, 1988Google Scholar
- 61.Repin VS, Dolgov VV, Zaikina OE, Novikov ID, Antonov AS, Nikolaeva MA, Smirnov VN: Heterogeneity of endothelium in human aorta. A quantitative analysis by scanning electron microscopy. Atherosclerosis 50: 35–52, 1984Google Scholar
- 62.Tokunaga O, Fan J, Watanabe T: Atherosclerosis- and agerelated multinucleated variant endothelial cells in primary culture from human aorta. Am J Pathol 135: 967–976, 1989Google Scholar
- 63.Wilcox JN, Smith KM, Williams LT, Schwartz SM, Gordon D: Platelet-derived growth factor mRNA detection in human atherosclerotic plaques by in situ hybridization. J Clin Invest 82: 1134–1143,1988Google Scholar
- 64.Pober JS, Cotran RS: Cytokines and endothelial cell biology. Physiol Rev 70: 427–451, 1990Google Scholar
- 65.Salomon RN, Hughes CCW, Schoen FJ, Payne DD, Pober JS, Libby P: Human coronary transplantation-associated arteriosclerosis. Evidence for a chronic immune reaction to activated graft endothelial cells. Am J Pathol 138: 791–798, 1991Google Scholar
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