Archives of Dermatological Research

, Volume 287, Issue 2, pp 193–197

Demonstration of interleukin-2, interleukin-4 and interleukin-6 in sera from patients with localized scleroderma

  • H. Ihn
  • S. Sato
  • M. Fujimoto
  • K. Kikuchi
  • K. Takehara
Original Paper

DOI: 10.1007/BF01262331

Cite this article as:
Ihn, H., Sato, S., Fujimoto, M. et al. Arch Dermatol Res (1995) 287: 193. doi:10.1007/BF01262331

Abstract

Localized scleroderma has been reported to be accompanied by immunological abnormalities related to B cells, but little is known about T-cell activation in this disease. In this study, serum levels of interleukin-2 (IL-2), interleukin-4 (IL-4) and interleukin-6 (IL-6), which are known to be released by activated T cells, were determined using a sensitive enzyme-linked immunosorbent assay in 48 patients with localized scleroderma and 20 with systemic sclerosis, and in 20 healthy control subjects. IL-2, IL-4 and IL-6 were detected in serum from patients with localized scleroderma but not in that from healthy controls. The presence of antihistone antibodies correlated significantly with elevated IL-4 and IL-6 levels. Decreased serum levels of IL-2, IL-4 and IL-6 paralleled improvement in cutaneous sclerosis. Frequent detection of these lymphokines in serum from patients with localized scleroderma reflects T-cell activation in this disorder.

Key words

Localized scleroderma Interleukin-2 Interleukin-4 Interleukin-6 

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • H. Ihn
    • 1
  • S. Sato
    • 1
  • M. Fujimoto
    • 1
  • K. Kikuchi
    • 1
  • K. Takehara
    • 1
  1. 1.Department of Dermatology, Faculty of MedicineUniversity of TokyoTokyoJapan

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