Journal of Neural Transmission

, Volume 46, Issue 4, pp 303–312 | Cite as

The effect of etoperidone, a new potential antidepressant drug, on the central serotonin system

  • E. Przegaliński
  • A. Lewandowska


The effect of etoperidone-a non-tricyclic potential antidepressant drug-on the central serotonergic system was studied. It was demonstrated that this compound inhibited the head twitch reaction induced by 5-HTP in mice and rats (ED50 values amounted to 2.89 and 2.29 mg/kg i.p. respectively). In the flexor reflex preparation in spinal rats etoperidone used in doses lower than 1 mg/kg i.v. produced no effect, while doses of 1 mg/kg i.v. and higher had a stimulating action which occured 10–15 min after injection. This stimulating action was abolished by 5-HT antagonists (cyproheptadine, danitracen) and by the drug metabolism inhibitor SKF-525 A, but not by the 5-HT uptake inhibitor clomipramine. Etoperidone given in a dose of 0.5 mg/kg i.v. had no effect on the stimulating action of serotoninmimetics (LSD, quipazine, fenfluramine) on the flexor reflex, but it abolished the effect of LSD in rats pretreated with SKF-525A. The above findings indicate that etoperidone has a biphasic action on the serotonergic transmission, revealing characteristics of the 5-HT antagonist and agonist. The agonistic action is probably connected with the formation of a metabolite.


Clomipramine Stimulate Action Fenfluramine Serotonergic System Uptake Inhibitor 
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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • E. Przegaliński
    • 1
  • A. Lewandowska
    • 1
  1. 1.Institute of PharmacologyPolish Academy of SciencesKrakówPoland

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