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Journal of Neural Transmission

, Volume 46, Issue 4, pp 303–312 | Cite as

The effect of etoperidone, a new potential antidepressant drug, on the central serotonin system

  • E. Przegaliński
  • A. Lewandowska
Article

Summary

The effect of etoperidone-a non-tricyclic potential antidepressant drug-on the central serotonergic system was studied. It was demonstrated that this compound inhibited the head twitch reaction induced by 5-HTP in mice and rats (ED50 values amounted to 2.89 and 2.29 mg/kg i.p. respectively). In the flexor reflex preparation in spinal rats etoperidone used in doses lower than 1 mg/kg i.v. produced no effect, while doses of 1 mg/kg i.v. and higher had a stimulating action which occured 10–15 min after injection. This stimulating action was abolished by 5-HT antagonists (cyproheptadine, danitracen) and by the drug metabolism inhibitor SKF-525 A, but not by the 5-HT uptake inhibitor clomipramine. Etoperidone given in a dose of 0.5 mg/kg i.v. had no effect on the stimulating action of serotoninmimetics (LSD, quipazine, fenfluramine) on the flexor reflex, but it abolished the effect of LSD in rats pretreated with SKF-525A. The above findings indicate that etoperidone has a biphasic action on the serotonergic transmission, revealing characteristics of the 5-HT antagonist and agonist. The agonistic action is probably connected with the formation of a metabolite.

Keywords

Clomipramine Stimulate Action Fenfluramine Serotonergic System Uptake Inhibitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • E. Przegaliński
    • 1
  • A. Lewandowska
    • 1
  1. 1.Institute of PharmacologyPolish Academy of SciencesKrakówPoland

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