Journal of Neural Transmission

, Volume 35, Issue 3, pp 207–215 | Cite as

Glutamate-type hypothalamic-pituitary syndrome in mice treated with aspartate or cysteate in infancy

  • B. Schainker
  • J. W. Olney


Monosodium L-glutamate (MSG), a neuroexcitatory amino acid is known to destroy hypothalamic (arcuate nucleus) neurons and give rise to subsequent obesity, skeletal stunting and reduced mass of pituitaries, ovaries and testes when administered subcutaneously to infant rodents. Here it is demonstrated that the same hypothalamic lesion and syndrome of neuroendocrine manifestations occurs following treatment of infant mice with either of two other neuroexcitatory amino acids (L-cysteic or L-aspartic acids) which destroy arcuate neurons but not from a structurally related amino acid (DL-α-aminoadipic acid) which lacks neuroexcitatory properties and spares arcuate neurons.


Public Health Obesity Aspartate Monosodium Arcuate Nucleus 
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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • B. Schainker
    • 1
  • J. W. Olney
    • 1
  1. 1.Department of PsychiatryWashington University School of MedicineSt. LouisUSA

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