Journal of Neural Transmission

, Volume 75, Issue 3, pp 221–226

The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine-depleted mice

  • Maria Carlsson
  • A. Carlsson
Short Note

Summary

It was shown in the present study that the selective non-competitive N-methyl-D-aspartate (NMDA) antagonist MK-801 [(+)-5-methyl-10,11-dihydroxy-5H-dibenzo(a,d)cyclohepten-5,10-imine] caused a pronounced and dose-dependent increase in locomotion in mice pretreated with a combination of reserpine and α-methyl-para-tyrosine. Haloperidol pretreatment did not antagonize the MK-801-induced stimulation of locomotion. The findings are discussed in relation to the concept of a corticostriatothalamocortical negative feedback loop serving to protect the cortex from an overload of information and hyperarousal. Such a feedback loop would encompass i.a. corticostriatal glutamatergic neurons and it would be modulated by mesencephalostriatal dopaminergic neurons.

Keywords

MK-801 NMDA receptors glutamate dopamine brain mouse 

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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • Maria Carlsson
    • 1
  • A. Carlsson
    • 1
  1. 1.Department of PharmacologyUniversity of GöteborgGöteborgSweden

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