Archiv für die gesamte Virusforschung

, Volume 12, Issue 2, pp 250–258 | Cite as

An attempt to demonstrate the minimal number (estimated by probit analysis) of biological units of chicken embryo-propagated distemper virus required to immunize ferrets and minks

  • S. -E. Svehag
  • J. R. Gorham
Article
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Summary

The method of probit analysis was applied to the estimation of chicken embryo-propagated distemper virus infectivity.

Ferrets vaccinated with a lowest estimated number of 2 and minks with 32 biological units of embryo-propagated distemper virus were immune when challenged with varying concentrations of virulent distemper virus. The minimal number of biological units needed to initiate a detectable immune response was not established.

No quantitative relationship could be demonstrated between immunizing doses of attenuated virus and challenge doses of virulent distemper virus.

Keywords

Immune Response Infectious Disease Virus Infectivity Quantitative Relationship Probit Analysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag 1962

Authors and Affiliations

  • S. -E. Svehag
    • 1
  • J. R. Gorham
    • 1
  1. 1.Fur Animal Disease Laboratory, Animal Disease and Parasite Division, U. S. Department of Agriculture and Washington Agricultural Experiment StationWashington State UniversityPullman

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