Autoradiographic localization of dopamine D1 and D2 receptors in the brain of several mammalian species

  • M. Camps
  • P. H. Kelly
  • J. M. Palacios
Full Papers

Summary

Dopamine D 1 and D 2 receptor distributions were studied in the brain of the mouse, rat, guinea pig, cat and monkey by means of in vitro quantitative autoradiography using [3H]SCH 23390 and [3H]CV 205–502 to label D 1 and D 2 subtypes respectively.

The distribution of both subtypes of receptors was similar within the basal ganglia of all species investigated. The highest densities for both subtypes were found in the nucleus caudatus, putamen, nucleus accumbens, olfactory tubercle and substantia nigra.

Outside of the basal ganglia, differences in the distribution of both receptors were found among the species examined in regions such as cerebellum, cortex, hippocampus, superior colliculus and olfactory bulb.

In all species D 1 receptor densities were higher than those of D 2. The absolute amount of both subtypes, however, varied among species.

These results indicate that dopamine receptor distribution is well preserved in the basal ganglia during evolution, although differences among species exist in their distribution outside the basal ganglia and their absolute amount.

Keywords

D1 D2 dopamine receptors monkey cat guinea pig basal ganglia hippocampus cerebellum 

Abbreviations used in figures

A

corpus amygdalae

Acc

nucleus accumbens

CA 1

CA 1 subfield of the hippocampus

CA 2

CA 2 subfield of the hippocampus

CgC

cingular cortex

Cls

claustrum

Cd

nucleus caudatus

CPu

caudate-putamen

DA

dopamine

DG

dentate gyrus of the hippocampus

EP

nucleus entopeduncularis

GP

globus pallidus

GPl

globus pallidus, pars lateralis

GPm

globus pallidus, pars medialis

gr

granular layer of the cerebellum

IP

nucleus interpeduncularis

LS

lateral septum

mol

molecular layer of the cerebellum

OT

olfactory tubercle

Pk

Purkinje cell layer of the cerebellum

Pu

putamen

SC

superior colliculus

snc

substantia nigra, pars compacta

snr

substantia nigra, pars reticulata

VTA

area ventralis tegmentalis

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • M. Camps
    • 1
  • P. H. Kelly
    • 1
  • J. M. Palacios
    • 1
  1. 1.Preclinical ResearchSandoz AGBaselSwitzerland

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