Journal of Neural Transmission

, Volume 39, Issue 3, pp 257–267 | Cite as

Serotonin, noradrenaline, dopamine metabolites in transcendental meditation-technique

  • M. Bujatti
  • P. Biederer
Short Communication


The highly significant increase of 5-HIAA (5-hydroxyindole-3-acetic acid) in Transcendental Meditation technique suggests systemic serotonin as “rest and fulfillment hormone” of deactivation-relaxation.

Furthermore 5-HT (5-hydroxytryptamine, serotonin) is considered to to be the EC-cell (enterochromaffine-cell) hormone requested byFujita andKobayashi and its role for EEG synchronisation via area postrema chemo-receptor as anti arousal agent is being discussed.

The significant decrease of the catecholamine metabolite VMA (vanillic-mandelic acid) in meditators, that is associated with a reciprocal increase of 5-HIAA supports as a feedback necessity the “rest and fulfillment response” versus “fight and flight”.

As the adreno medullary tissue serves for hormonal reinforcement of orthosympathetic activity, the Enterochromaffine Cell System (having taken the form of distinct organs in some species as octopus and discoglossus) is suggested to serve via serotonin for humoral reinforcement of parasympathetic activity in deep relaxation.


Serotonin Area Postrema Adreno Enterochromaffine Cell Transcendental Meditation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • M. Bujatti
    • 1
  • P. Biederer
    • 1
  1. 1.Ludwig Boltzmann Institute for NeurochemistryGeriatric Hospital Lainz Pav. XIViennaAustria

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