Equol and other compounds from bovine urine as monoamine oxidase inhibitors
Equol, its methylated derivative, and a carbazole, all isolated from bovine urine, are relatively potent inhibitors of monoamine oxidase with IC50 values of 158, 28, and 16μM respectively (using 83μM tyramine as substrate). The probable dietary origin of these compounds suggests that “natural” monoamine oxidase inhibitors may be more widespread than had previously been suspected.
Key wordsEquol monoamine oxidase inhibition benzodiazepine receptor binding inhibition bovine urine dietary isoflavans
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