Journal of Neural Transmission

, Volume 65, Issue 2, pp 103–114

Actions of theβ-carboline ZK 93426 in an animal test of anxiety and the holeboard: Interactions with Ro 15-1788

  • Sandra E. File
  • S. Pellow
  • L. H. Jensen
Original Papers

DOI: 10.1007/BF01256486

Cite this article as:
File, S.E., Pellow, S. & Jensen, L.H. J. Neural Transmission (1986) 65: 103. doi:10.1007/BF01256486

Summary

The effects of theβ-carboline ZK 93426, a putative benzodiazepine receptor antagonist, were investigated in the social interaction test of anxiety and in the holeboard. Like the receptor antagonist Ro 15-1788, ZK 93426 (2.5–10 mg/kg) caused a specific reduction in social interaction (interpreted as an anxiogenic effect) and caused a significant elevation in exploratory head-dipping (5 mg/kg). When low (ineffective) doses of both compounds (1 mg/kg ZK 93426; 4 mg/kg Ro 15-1788) were administered together they significantly reduced social interaction. No further reductions in social interaction were observed when effective doses of both compounds (5 mg/kg ZK 93426; 10 mg/kg Ro 15-1788) were tested in combination; it is likely that this is due to almost total benzodiazepine receptor occupancy at effective doses of either compound. When doses of each compound (5 mg/kg ZK 93426; 10 mg/kg Ro 15-1788) that resulted in stimulation of head-dipping were examined in combination, the elevation in exploration was no longer observed. Since at higher doses of both compounds there is an attenuation of the elevation in head-dipping, it is again likely that the effects of the two compounds are additive.

Key words

Benzodiazepines β-carbolines anxiety exploration endogenous ligand 

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • Sandra E. File
    • 1
  • S. Pellow
    • 2
  • L. H. Jensen
    • 3
  1. 1.MRC Neuropharmacology Research Group, Department of PharmacologyThe School of Pharmacy, University of LondonUK
  2. 2.Département de Pharmacologie, Faculté de Médecine Pitié-SalpétrièreUniversité de ParisFrance
  3. 3.Research DivisionA/S FerrosanSoeborgDenmark

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